Evidence map›Paper›PMID 41530486›Full record

ReviewPediatric research2026

Maternal phylloquinone intake and early neurodevelopment: implications for prenatal nutrition.

Khaled Saad, Zakaria M Abdel-Sadek, Eman F Gad, Ahmad Roshdy Ahmad, Amira Elhoufey, Ahmed Tayeb B Alanazi, Mohamad-Hani Temsah, Mostafa M Embaby

Abstract readReview
PubMed Publisher
In one paragraph

Review in Pediatric research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Khaled SaadDepartment of Pediatrics, Assiut University, Assiut, Egypt. Khaled.ali@med.au.edu.eg.
Zakaria M Abdel-SadekDepartment of Pediatrics, Faculty of Medicine for Girls, Al-Azhar University, Assiut, Egypt.
Eman F GadDepartment of Pediatrics, Assiut University, Assiut, Egypt.
Ahmad Roshdy AhmadDepartment of Pediatrics, College of Medicine, Jouf University, Sakaka, Saudi Arabia.
Amira ElhoufeyDepartment of Community Health Nursing, Alddrab University College, Jazan University, Jazan, Saudi Arabia.
Ahmed Tayeb B AlanaziPrince Mohammed Bin Abdulaziz Medical City, Jouf, Saudi Arabia.
Mohamad-Hani TemsahDepartment of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia.
Mostafa M EmbabyDepartment of Pediatrics, Assiut University, Assiut, Egypt.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

impactVitamin K supports neurodevelopment through sphingolipid regulation critical for myelination and neuronal integrity, anti-inflammatory effects via NF-κB pathway inhibition, and improved maternal glucose metabolism and insulin sensitivity. Current prenatal recommendations of vitamin K (70-90 µg/day), based solely on coagulation needs, may be insufficient for optimal brain development. A target of 140 µg/day warrants consideration in future guidelines. Routine assessment of vitamin K status in prenatal care offers a safe and low-cost opportunity to support neurodevelopment and reduce developmental inequities at the population level.

Indexed as

BrainMaternal Nutritional Physiological PhenomenaNeurodevelopmentPrenatal Nutritional Physiological PhenomenaVitamin K 1AnimalsDevelopmental Origins of Health and DiseaseFemaleHumansPregnancyPrenatal CareVitamin K 1

Identifiers

PMID41530486

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.