Evidence map›Paper›PMID 41530398›Full record

ArticleScientific reports2026

Association between hydrogen gas inhalation and cardiac output in an asphyxiated piglet model.

Kosuke Sakamoto, Shinji Nakamura, Toui Tsuchiya, Tsutomu Mitsuie, Yasuhiro Nakao, Yinmon Htun, Takayuki Yokota, Kota Inoue, Eri Inoue, Takayuki Wakabayashi and 6 more

Erratum issuedAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

16 authors.

Kosuke SakamotoDepartment of Cardiac surgery, Faculty of Medicine, Kagawa University, Kitagun, Kagawa, Japan.
Shinji NakamuraDepartment of Pediatrics, Faculty of Medicine, Kagawa University, Kitagun, Kagawa, Japan. nakamura.shinji@kagawa-u.ac.jp.
Toui TsuchiyaDepartment of Pediatrics, Faculty of Medicine, Kagawa University, Kitagun, Kagawa, Japan.
Tsutomu MitsuieMedical Engineering Equipment Management Center, Kagawa University Hospital, Kagawa University, Kitagun, Kagawa, Japan.
Yasuhiro NakaoDepartment of Pediatrics, Faculty of Medicine, Kagawa University, Kitagun, Kagawa, Japan.
Yinmon HtunDepartment of Pediatrics, Faculty of Medicine, Kagawa University, Kitagun, Kagawa, Japan.
Takayuki YokotaDepartment of Pediatrics, Faculty of Medicine, Kagawa University, Kitagun, Kagawa, Japan.
Kota InoueDepartment of Pediatrics, Faculty of Medicine, Kagawa University, Kitagun, Kagawa, Japan.
Eri InoueDepartment of Pediatrics, Faculty of Medicine, Kagawa University, Kitagun, Kagawa, Japan.
Takayuki WakabayashiDepartment of Pediatrics, Faculty of Medicine, Kagawa University, Kitagun, Kagawa, Japan.
Aya MorimotoMaternal Perinatal Center, Faculty of Medicine, Kagawa University, Kitagun, Kagawa, Japan.
Kosuke KoyanoMaternal Perinatal Center, Faculty of Medicine, Kagawa University, Kitagun, Kagawa, Japan.
Yukihiko KonishiDepartment of Education for Children with Special Needs, Faculty of Education, Kagawa University, Kitagun, Kagawa, Japan.
Takashi IwaseDepartment of Pediatrics, Faculty of Medicine, Kagawa University, Kitagun, Kagawa, Japan.
Taikou HoriiDepartment of Cardiac surgery, Faculty of Medicine, Kagawa University, Kitagun, Kagawa, Japan.
Takashi KusakaDepartment of Pediatrics, Faculty of Medicine, Kagawa University, Kitagun, Kagawa, Japan.

Funding

Japan Society for the Promotion of Science 22K07822Japan Society for the Promotion of Science 22K15922Japan Society for the Promotion of Science 23K07332Japan Society for the Promotion of Science 25K19202JSPS 22K15923JSPS 22K18171Kagawa University Faculty of Medicine School of Medicine Alumni Association Sanjukai Research Aid grants R5-1
6 · The paper itself

Abstract

About 80% of neonates with hypoxic-ischaemic encephalopathy (HIE) have cardiovascular dysfunction and are vulnerable to late-onset injury due to disrupted cerebral blood flow and metabolism. We previously reported the neuroprotective effect of hydrogen (H2) gas. This study investigated the effects of H2 gas inhalation on cardiac function in piglets after hypoxia-ischaemia (HI). Seventeen piglets ≤ 24 h old were subjected to HI insult for approximately 40 min and, after 10 min of resuscitation, were divided into an HI group (n = 10) and an HI-H2 gas inhalation group (2.2%–2.7% H2 gas for 6 h; n = 7). We examined biventricular single stroke volume (SV) and cardiac output (CO) within 6 h after HI insult using transthoracic echocardiography. The HI group (n = 10) showed a transient increase in SV and CO followed by a decline. In contrast, the HI-H2 group (n = 7) experienced a increase in right ventricular SV and CO, with a mild decrease in left ventricular parameters. Notably, right CO were significantly higher at 5 h after insult in the HI-H2 group (p = 0.023). Hydrogen gas inhalation may help preserve right ventricular performance after asphyxia.

Indexed as

AsphyxiaAsphyxia NeonatorumCardiac OutputHydrogenHypoxia-Ischemia, BrainAdministration, InhalationAnimalsAnimals, NewbornDisease Models, AnimalEchocardiographyStroke VolumeSwineHydrogenAsphyxiaHydrogen gasNeonatePigletRight cardiac output

Identifiers

PMID41530398
PMCPMC12881564

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.