SynthesisChild's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery2026
Impact of molecular subtypes on postoperative hydrocephalus following resection of posterior fossa medulloblastoma and ependymoma in children: A systematic review and meta-analysis.
Synthesis in Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
objectiveThe objective of this systematic review was to investigate the possible impact of tumor molecular subtype on the risk of postoperative hydrocephalus following resection of posterior fossa ependymomas and medulloblastomas in children.
methodsA Preferred Reporting Items for Systematic Reviews and Meta-Analyses guideline based systematic literature review and meta-analysis was performed using the PubMed and Embase databases. The final searches were conducted on February 1st, 2025. Predetermined eligibility criteria were based on the Population, Intervention, Comparison and Study design framework. A risk of bias analysis was performed using the Risk of Bias In Non-randomized Studies of Exposures tool. Count data was pooled across the included studies with the addition of a 10-year nationwide cohort from Denmark (DK cohort). Extracted data from medulloblastoma studies were compared using chi-squared tests and calculations of relative risks.
resultsA total of four studies were included, three of which pertained to medulloblastoma (MB). In total, postoperative hydrocephalus was reported in 22.4% (68/304) of children with MB. The lowest rate was observed for MB
conclusionsIn this systematic literature review, we investigated the potential association between tumor molecular subtype in children with posterior fossa EPN and MB and postoperative hydrocephalus. Here, we show that the rate of postoperative hydrocephalus is significantly lower for MB
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