Evidence map›Paper›PMID 41530355›Full record

Trial reportSurgical endoscopy2026

Effect of intraoperative autonomic neural blockade on early postoperative outcomes after laparoscopic cholecystectomy: a double-blind randomized controlled trial.

Jorge Daes, Andrés Hanssen, Elika Luque, Jose Mercado, Daniel Garcia De la Rosa, Eric M Pauli

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in Surgical endoscopy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07655908 (Targeted Temporary In Situ Catheter Redosing of Autonomic Neural Blockade for Breakthrough Symptoms After Laparoscopic Sleeve Gastrectomy), which is not on this map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07655908 nanot yet recruitingnot on this map

Targeted Temporary In Situ Catheter Redosing of Autonomic Neural Blockade for Breakthrough Symptoms After Laparoscopic Sleeve Gastrectomy

TypeinterventionalSponsorUniversidad Simón BolívarRan2026 to 2027Enrolled30ConditionsPain, Acute Post-Operative, Nausea and Vomiting, PostoperativeArmsBupivacaine 0.5% and Dexamethasone via Temporary Catheter
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Jorge DaesDivision of Minimally Invasive and Bariatric SurgeryDepartment of Surgery, Clínica Iberoamérica, Carrera 50 No. 79-223, PH B., Barranquilla, Colombia. jorgedaez@gmail.com.ORCID http://orcid.org/0000-0002-3125-6602
Andrés HanssenDivision of Minimally Invasive and Bariatric SurgeryDepartment of Surgery, Clínica Iberoamérica, Carrera 50 No. 79-223, PH B., Barranquilla, Colombia.
Elika LuqueDivision of Minimally Invasive and Bariatric SurgeryDepartment of Surgery, Clínica Iberoamérica, Carrera 50 No. 79-223, PH B., Barranquilla, Colombia.
Jose MercadoDivision of Minimally Invasive and Bariatric SurgeryDepartment of Surgery, Clínica Iberoamérica, Carrera 50 No. 79-223, PH B., Barranquilla, Colombia.
Daniel Garcia De la RosaDivision of Minimally Invasive and Bariatric SurgeryDepartment of Surgery, Clínica Iberoamérica, Carrera 50 No. 79-223, PH B., Barranquilla, Colombia.
Eric M PauliDivision of Minimally Invasive and Bariatric Surgery, Department of Surgery, Penn State Health Milton S. Hershey Medical Center, Hershey, PA, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAdvances in minimally invasive techniques, enhanced recovery protocols, and regional pain management have improved postoperative outcomes. However, visceral pain and postoperative nausea and vomiting (PONV) continue to be challenging after minimally invasive procedures. Intraoperative autonomic neural blockade (ANB), which interrupts the afferent nerves transmitting these impulses, has effectively addressed these challenges, as demonstrated in previous publications. This randomized trial evaluates its efficacy in laparoscopic cholecystectomy.

methodsIn this double-blind, randomized controlled trial, 62 patients undergoing elective laparoscopic cholecystectomy were assigned to receive ANB with Bupivacaine and Dexamethasone (intervention group) or no blockade (control group). All patients received standard TAP, subcostal blocks, low-pressure pneumoperitoneum, and ERAS-based care. The primary outcome was Acetaminophen consumption. Rescue analgesic use was assessed at 1, 24, and 48 h postoperatively. Secondary outcomes included pain scores at 1, 24, and 48 h and the incidence of nausea and vomiting.

resultsBaseline characteristics were similar between groups. Pain scores were significantly lower in the ANB group at 1, 24, and 48 h (0.42 vs. 2.52 at 1h; p < 0.0001). Acetaminophen consumption was markedly reduced over 48 h (0.42 vs. 2.33 doses; p < 0.0001). Fewer patients required NSAIDs or Codeine rescue analgesia, and nausea/vomiting was less frequent in the ANB group. No adverse events were reported.

conclusionsThis study demonstrates that ANB significantly reduces the analgesic requirements and autonomic symptoms after laparoscopic cholecystectomy, even when added to comprehensive multimodal care. These findings support its broader use in minimally invasive surgery (MIS), where autonomic afferent input predominates by targeting the appropriate pathways.

Indexed as

Autonomic Nerve BlockCholecystectomy, LaparoscopicPostoperative PainAcetaminophenAdultAnesthetics, LocalBupivacaineDexamethasoneDouble-Blind MethodFemaleHumansIntraoperative CareMaleMiddle AgedPostoperative Nausea and VomitingTreatment OutcomeAcetaminophenAnesthetics, LocalBupivacaineDexamethasoneAutonomic neural blockadeLocal anestheticsOpioidsPostoperative nausea and vomitingVisceral pain

Identifiers

PMID41530355

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.