Evidence map›Paper›PMID 41530353›Full record

ArticleSurgical endoscopy2026

Safety and outcomes of laparoscopic bile duct exploration: a UK-wide multi-centre study (R-ALiCE).

Somaiah Aroori, Tanase Andrei, Ahmad Nassar, Tarek Z Katbeth, Scott MacDonald, Rhona Kilpatrick, Andrew Healey, Artur Zanellato, Saskia Clark-Stewart, Simon Paterson-Brown and 59 more

Erratum issuedAbstract readMulticenter Study
PubMed Publisher
In one paragraph

Article in Surgical endoscopy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

69 authors.

Somaiah ArooriConsultant HPB and Transplant Surgeon, University Hospitals Plymouth NHS Trust, Peninsula Medical School, University of Plymouth England, Plymouth, England, UK. s.aroori@nhs.net.ORCID http://orcid.org/0000-0002-5613-6463
Tanase AndreiConsultant HPB and Transplant Surgeon, University Hospitals Plymouth NHS Trust, Peninsula Medical School, University of Plymouth England, Plymouth, England, UK.
Ahmad NassarUniversity Hospital Monklands, NHS Lanarkshire, Airdrie, ML6 0JS, UK.
Tarek Z KatbethUniversity Hospital Monklands, NHS Lanarkshire, Airdrie, ML6 0JS, UK.
Scott MacDonaldUniversity Hospital Monklands, NHS Lanarkshire, Airdrie, ML6 0JS, UK.
Rhona KilpatrickUniversity Hospital Monklands, NHS Lanarkshire, Airdrie, ML6 0JS, UK.
Andrew HealeyRoyal Infirmary of Edinburgh, NHS Lothian, Edinburgh, Scotland, UK.
Artur ZanellatoRoyal Infirmary of Edinburgh, NHS Lothian, Edinburgh, Scotland, UK.
Saskia Clark-StewartRoyal Infirmary of Edinburgh, NHS Lothian, Edinburgh, Scotland, UK.
Simon Paterson-BrownRoyal Infirmary of Edinburgh, NHS Lothian, Edinburgh, Scotland, UK.
Vivienne GoughRoyal Alexandra Hospital, Paisley - NHS Greater Glasgow and Clyde, Paisley, PA2 9PN, Scotland, UK.
Chee Siong WongRoyal Alexandra Hospital, Paisley - NHS Greater Glasgow and Clyde, Paisley, PA2 9PN, Scotland, UK.
Laura McMurrayRoyal Alexandra Hospital, Paisley - NHS Greater Glasgow and Clyde, Paisley, PA2 9PN, Scotland, UK.
Alberto Martinez-IslaLondon North West University Healthcare NHS Trust, Harrow, HA1 3UJ, UK.
Lalin NavaratneLondon North West University Healthcare NHS Trust, Harrow, HA1 3UJ, UK.
Fatima SenraLondon North West University Healthcare NHS Trust, Harrow, HA1 3UJ, UK.
Matyas FehervariLondon North West University Healthcare NHS Trust, Harrow, HA1 3UJ, UK.
Richard MorganGlan Clwyd Hospital - Betsi Cadwaladr University Health Board, Bodelwyddan, Rhyl, LL18 5UJ, UK.
Sreedutt MuraliGlan Clwyd Hospital - Betsi Cadwaladr University Health Board, Bodelwyddan, Rhyl, LL18 5UJ, UK.
Mostafa AbdelkarimGlan Clwyd Hospital - Betsi Cadwaladr University Health Board, Bodelwyddan, Rhyl, LL18 5UJ, UK.
Gowtham S VenkatesanRoyal Cornwall Hospital, Treliske, Truro, UK.
Ian FinlayRoyal Cornwall Hospital, Treliske, Truro, UK.
Mahmoud Al-ArdahRoyal Cornwall Hospital, Treliske, Truro, UK.
Hannah RottenburgRoyal Cornwall Hospital, Treliske, Truro, UK.
Ashraf RasheedRoyal Gwent Hospital - Aneurin Bevan University Health Board, Caerleon, Wales, UK.
Harriet WhewellRoyal Gwent Hospital - Aneurin Bevan University Health Board, Caerleon, Wales, UK.
Tamsin BoyceRoyal Gwent Hospital - Aneurin Bevan University Health Board, Caerleon, Wales, UK.
Stuart MercerQueen Alexandra Hospital, Portsmouth Hospitals NHS Trust, Portsmouth, PO6 3LY, UK.
Iain WilsonQueen Alexandra Hospital, Portsmouth Hospitals NHS Trust, Portsmouth, PO6 3LY, UK.
Samantha BodyQueen Alexandra Hospital, Portsmouth Hospitals NHS Trust, Portsmouth, PO6 3LY, UK.
Imran BhattiUniversity Hospitals of Derby and Burton NHS Foundation Trust, Derby, UK.
Altaf AwanUniversity Hospitals of Derby and Burton NHS Foundation Trust, Derby, UK.
Javed LatifUniversity Hospitals of Derby and Burton NHS Foundation Trust, Derby, UK.
Nienke WarnaarEast Suffolk and North Essex NHS Foundation Trust, Colchester, UK.
Sreelakshmi SureshEast Suffolk and North Essex NHS Foundation Trust, Colchester, UK.
Anahita ShahmiriEast Suffolk and North Essex NHS Foundation Trust, Colchester, UK.
Cazz CroxonEast Suffolk and North Essex NHS Foundation Trust, Colchester, UK.
Andrew G N RobertsonVictoria Hospital, NHS Fife, Kirkcaldy, Scotland, UK.
Peter J DriscollVictoria Hospital, NHS Fife, Kirkcaldy, Scotland, UK.
Danielle ClydeVictoria Hospital, NHS Fife, Kirkcaldy, Scotland, UK.
Gabriele MarangoniUniversity Hospitals Coventry & Warwickshire, Coventry, CV2 2DX, UK.
Jawad AhmadUniversity Hospitals Coventry & Warwickshire, Coventry, CV2 2DX, UK.
Suzanne FitzpatrickUniversity Hospitals Coventry & Warwickshire, Coventry, CV2 2DX, UK.
Michael SilvaOxford University Hospitals NHS Foundation Trust, Oxford, UK.
Syed Hussain AbbasOxford University Hospitals NHS Foundation Trust, Oxford, UK.
Carlo CeresaOxford University Hospitals NHS Foundation Trust, Oxford, UK.
Moustafa MouradWorcestershire Acute Hospitals NHS Trust, Worcester, England, UK.
Ahmed ElmaradnyWorcestershire Acute Hospitals NHS Trust, Worcester, England, UK.
Katerina Thomas-FernandezWorcestershire Acute Hospitals NHS Trust, Worcester, England, UK.
Jed MaliyilWorcestershire Acute Hospitals NHS Trust, Worcester, England, UK.
Michael PellenHull University Teaching Hospitals NHS Trust, Hull, HU3 2JZ, England, UK.
Alex WilkinsHull University Teaching Hospitals NHS Trust, Hull, HU3 2JZ, England, UK.
Shahani NazirHull University Teaching Hospitals NHS Trust, Hull, HU3 2JZ, England, UK.
Heather SpenceHull University Teaching Hospitals NHS Trust, Hull, HU3 2JZ, England, UK.
Ewen A GriffithsUniversity Hospitals Birmingham NHS Foundation Trust, Birmingham, UK.
Oluwasina DadaUniversity Hospitals Birmingham NHS Foundation Trust, Birmingham, UK.
Keval DabhiUniversity Hospitals Birmingham NHS Foundation Trust, Birmingham, UK.
Mohammed HoqueUniversity Hospitals Birmingham NHS Foundation Trust, Birmingham, UK.
Giuseppe GarceaUniversity Hospitals of Leicester NHS Trust, Leicester, England, UK.
Tareq Al SaoudiUniversity Hospitals of Leicester NHS Trust, Leicester, England, UK.
Suchita BahriUniversity Hospitals of Leicester NHS Trust, Leicester, England, UK.
Samir RokedUniversity Hospitals of Leicester NHS Trust, Leicester, England, UK.
Streeter AdamUniversity of Plymouth, Plymouth, England, UK.
Dorothy KuekConsultant HPB and Transplant Surgeon, University Hospitals Plymouth NHS Trust, Peninsula Medical School, University of Plymouth England, Plymouth, England, UK.
Sera SarsamConsultant HPB and Transplant Surgeon, University Hospitals Plymouth NHS Trust, Peninsula Medical School, University of Plymouth England, Plymouth, England, UK.
Pooja DhavalaConsultant HPB and Transplant Surgeon, University Hospitals Plymouth NHS Trust, Peninsula Medical School, University of Plymouth England, Plymouth, England, UK.
Cramp MatthewConsultant HPB and Transplant Surgeon, University Hospitals Plymouth NHS Trust, Peninsula Medical School, University of Plymouth England, Plymouth, England, UK.
Danda AshwinConsultant HPB and Transplant Surgeon, University Hospitals Plymouth NHS Trust, Peninsula Medical School, University of Plymouth England, Plymouth, England, UK.
R-ALiCE Collaborators

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe optimal management approach for suspected or confirmed bile duct stones (BDS) in patients with symptomatic gallstones remains unclear. This study evaluates outcomes and safety profile of laparoscopic common bile duct exploration and cholecystectomy (LCBDE) from a UK-wide multi-centre study.

methodsThe "Retrospective Audit of Laparoscopic Common Bile Duct Exploration (R-ALiCE)", study involved 18 centres across the UK. Adult patients undergoing LCBDE for BDS between 01/01/2015 and 31/12/2019 were included. Patients who underwent LCBDE for non-stone disease and as part of another operation were excluded from the study.

results1,689 patients (68.2% female, median age: 59 years) were included. The open conversion rate was 5% (n = 84). Trans-cystic LCBDE (TC-LCBDE) was attempted in 71.5% (n = 1207) (success rate, 77.6%, n = 937). Trans-choledochal-LCBDE (TD-LCBDE) was performed in 41% (694), with 28.5% being direct-to-trans-ductal explorations. The TD-LCBDE success rate was 93.4% (n = 648). The bile leak rate was 4.4% (n = 75) (61, 8.8% in TD-LCBDE vs. 14,1.5% in the TC-LCBDE, Odds Ratio = 6.76; 95% CI 3.75-12.19; P < 0.001). The retained stone rate was 4.4% (n = 74) (4.1% in TC-LCBDE vs. 4.8% in TD-LCBDE; P = 0.53). Postoperative pancreatitis occurred in 0.9% (n = 15) (0.8% for TC-LCBDE vs. 1% for TD-LCBDE; P = 0.65). The bile duct stricture rate was 0 at 90-day follow-up. The 30-day readmission rate was 7.5% (n = 127). The median length of stay was 3 days (range 2-7). Overall morbidity and Clavien-Dindo grade ≥ III complications rate were 18.7% (n = 316) and 8.8% (n = 149), respectively. The 30-day mortality rate was 0.4% (n = 7).

conclusionLCBDE is a safe and effective approach for managing BDS, with low rates of severe complications, including bile leak, postoperative pancreatitis, and retained stones. The trans-cystic approach is associated with a lower bile leak rate than the trans-ductal approach.

Indexed as

Cholecystectomy, LaparoscopicCommon Bile DuctGallstonesLaparoscopyAdultAgedFemaleHumansLength of StayMaleMiddle AgedPostoperative ComplicationsRetrospective StudiesTreatment OutcomeUnited KingdomBile duct explorationBile duct stonesERCPLaparoscopic

Identifiers

PMID41530353

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.