Cuproptosis of bronchial epithelial cells triggers airway remodeling in chronic asthma.

Min Wang, Chen Liu, Zheng Li, Yue Wang, Yanling Li, Fengyi Pei

Abstract read

In one paragraph

Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Min WangDepartment of Respiratory and Critical Care Medicine, The Affiliated Hospital of Hebei University, No.212, Yuhua East Road, Baoding, 071000, Hebei, China. 1243930091@qq.com.

Chen LiuDepartment of Hepatobiliary Surgery, The Affiliated Hospital of Hebei University, Baoding, 071000, Hebei, China.

Zheng LiDepartment of Respiratory and Critical Care Medicine, The Affiliated Hospital of Hebei University, No.212, Yuhua East Road, Baoding, 071000, Hebei, China.

Yue WangDepartment of Respiratory and Critical Care Medicine, The Affiliated Hospital of Hebei University, No.212, Yuhua East Road, Baoding, 071000, Hebei, China.

Yanling LiDepartment of Respiratory and Critical Care Medicine, The Affiliated Hospital of Hebei University, No.212, Yuhua East Road, Baoding, 071000, Hebei, China.

Fengyi PeiSchool of Clinical Medicine, Hebei University, Baoding, 071000, Hebei, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Airway remodeling is a critical cause of chronic asthma that is difficult to control. Cell death contributes to the development and progression of chronic asthma. However, the novel copper-dependent cell death, cuproptosis, and especially cuproptosis of bronchial epithelial cells, its role, and underlying mechanisms in airway remodeling are unclear. Repetitive OVA exposure was used to establish a mouse model of chronic asthma. The human bronchial epithelial cell line BEAS-2B (BEAS-2B cells) was incubated with recombinant human IL-4 (rhIL-4) and TGF-β1 to simulated airway remodeling in vitro. Cuproptosis increased after repetitive OVA exposure in chronic asthmatic mice, evidenced by increased Cu

Indexed as

Airway RemodelingAsthmaBronchiCopperCuproptosisEpithelial CellsAnimalsBronchoalveolar Lavage FluidCell LineChronic DiseaseDisease Models, AnimalEpithelial-Mesenchymal TransitionFemaleHumansInterleukin-4MiceCopperInterleukin-4Transforming Growth Factor beta1Airway remodelingBronchial epithelial cellsChronic asthmaCuproptosisFDX-1

Identifiers

PMID41530300

DOI10.1038/s41598-025-34574-3

PMCPMC12868725

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LicenceCC BY-NC-ND

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.