ArticleScientific reports2026
Comparative evaluation of ultrasound-assisted extraction and micelle-mediated extraction of bioactive compound from Acmella oleracea.
Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
This study compares two green extraction techniques: ultrasound-assisted extraction (UAE) and micelle-mediated extraction (MME) for isolating (2E,4E,8Z,10E)-N-isobutyl-2,4,8,10-dodecatetraenamide (IBDTA) from Acmella oleracea. EtOH was selected as the optimal solvent for UAE using Hansen solubility parameters, and extraction conditions including amplitude, extraction time, and solid-to-solvent ratio were systematically evaluated via response surface methodology. For MME, Tween 80 was used to form micelles to enhance the extraction process. The key parameters that were optimized included surfactant concentration, NaCl concentration, incubation time, and temperature. UAE achieved the highest extraction efficiency (25.94 µg/g crude extract) under 20% amplitude, 20 min, and a 1:5 solid-to-solvent ratio. MME yielded optimal extraction at 4% Tween 80, 10% NaCl, 40 min, and 80 °C, yielding 25.06 µg/g crude extract. The MME-extracted exhibited the highest anti-inflammatory activity (IC
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