ArticleScientific reports2026
Nomogram-based analysis of plasma albumin and C-reactive protein 30 days before bloodstream infection for 30-day mortality in Singapore and Denmark.
Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
This study aimed to assess the prognostic impact of plasma albumin (PA) and C-reactive protein (CRP), measured up to 30 days before a bloodstream infection (BSI), on 30-day mortality risk using nomogram models. Two cohorts comprising 5,221 inpatients from Singapore (SG) and 15,710 from Denmark (DK) with first-time BSIs were included from 2006 to 2016. Using multivariable logistic regression models, we analyzed the association between CRP and PA measured at different time-points (segmented into 5-day intervals, up to 30 days before the day of BSI (D0), and on D0) and 30-day mortality. Moreover, nomogram models assessed the relative attributions of PA and CRP to 30-day mortality risk. Both cohorts had similar 30-day mortality rates (SG: 17.4%, DK: 20.2%). Correlation coefficients between PA on D0 and PA in all 5-day intervals were high (range: 0.55/0.75) whereas it was only high between CRP on D0, and CRP measured 1-5 days before D0. In nomogram models, PA contributed most to the prognostic predictability (from 20 to 55%) whereas CRP contributed little (from 0.5 to 9%) regardless of time interval from D0. Albumin, measured up to 30 days before a BSI episode, was a strong prognosticator of 30-day mortality. Nomogram models enable rapid evaluation of a patient's prognosis.
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