Evidence map›Paper›PMID 41530254›Full record

ArticleScientific reports2026

CD13 activation assembles phosphoinositide (PI) signaling complexes to regulate the actin cytoskeleton.

Emily Meredith, Brian Aguilera, Riya Sharma, Nikhil Thimma, Fraser McGurk, Pengyu Zong, Lixia Yue, Linda H Shapiro, Mallika Ghosh

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Emily MeredithCenter for Vascular Biology, University of Connecticut Medical School, Farmington, CT, 06032, USA.
Brian AguileraCenter for Vascular Biology, University of Connecticut Medical School, Farmington, CT, 06032, USA.
Riya SharmaCenter for Vascular Biology, University of Connecticut Medical School, Farmington, CT, 06032, USA.
Nikhil ThimmaCenter for Vascular Biology, University of Connecticut Medical School, Farmington, CT, 06032, USA.
Fraser McGurkCenter for Vascular Biology, University of Connecticut Medical School, Farmington, CT, 06032, USA.
Pengyu ZongCalhoun Cardiology Center, University of Connecticut Medical School, Farmington, CT, 06032, USA.
Lixia YueCalhoun Cardiology Center, University of Connecticut Medical School, Farmington, CT, 06032, USA.
Linda H ShapiroCenter for Vascular Biology, University of Connecticut Medical School, Farmington, CT, 06032, USA. lshapiro@uchc.edu.
Mallika GhoshCenter for Vascular Biology, University of Connecticut Medical School, Farmington, CT, 06032, USA. mghosh@uchc.edu.

Funding

NIH HHS 1R21AI15University of Connecticut Research Excellence grantUniversity of Connecticut Health Center Research Excellence grant
6 · The paper itself

Abstract

Activation of transmembrane CD13 enables diverse cellular processes such as cell-cell and cell-matrix adhesion, endocytosis, and recycling of cell surface proteins by assembling and tethering protein complexes at the plasma membrane. Here, we identify a novel CD13-dependent protein assembly that regulates phosphoinositide (PI) signal transduction to impact actin dynamics and induce cell protrusions capable of propagating signals to distant cells. In response to cellular stress, the CD13-expressing human Kaposi's sarcoma-derived cell line (KS1767, KSCs) formed elongated protrusions that extend above the substrate and link non-adjacent cells, which is significantly diminished in CD13

Indexed as

Actin CytoskeletonCD13 AntigensPhosphatidylinositolsSignal TransductionADP-Ribosylation Factor 6ADP-Ribosylation Factorscdc42 GTP-Binding ProteinCell Line, TumorCell MembraneHumansras GTPase-Activating Proteinssrc-Family KinasesADP-Ribosylation Factor 6ADP-Ribosylation FactorsARF6 protein, humanCD13 Antigenscdc42 GTP-Binding ProteinIQ motif containing GTPase activating protein 1Phosphatidylinositolsras GTPase-Activating Proteinssrc-Family Kinases

Identifiers

PMID41530254
PMCPMC12880977

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.