ArticleScientific reports2026
Unveiling the anti-inflammatory activity of chloroform fraction of curcuma wallichii and its phytoconstituents by in vivo and in silico studies.
Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Curcuma genus has been widely used in folk medicine for its diverse medicinal properties. This study explored the in vitro and in vivo anti-inflammatory activity of the chloroform fraction of Curcuma wallichii (CFCW) and assessed the drug-likeness of identified compounds using computational tools. Phytochemical screening, gas chromatography-mass spectrometry (GC-MS), and high-performance liquid chromatography (HPLC) analyses of the CFCW confirmed the presence of different bioactive compounds. The in vitro methods include the human red blood cell (HRBC) membrane stabilization and egg albumin denaturation assays, where the fraction exhibited substantial anti-inflammatory activity in a dose-dependent manner. In vivo evaluation using the formalin-induced licking test and acetic acid-induced writhing test in Swiss albino mice showed noteworthy anti-inflammatory effects. The pharmacokinetic profile of the identified compounds was analyzed using pkCSM and SwissADME, which evaluated their drug-likeness properties and toxicity. Molecular docking studies were conducted to recognize possible drug candidates by predicting the binding affinity of the compounds against COX-2, using diclofenac sodium (DS) as a reference. Several molecules demonstrated even stronger binding affinities than the standard DS. Findings suggest that the plant C. wallichii contains bioactive compounds with significant anti-inflammatory effects. Further research is necessary to analyze their bioactivity, and clinical trials will be essential for the development of new anti-inflammatory drugs.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.