ArticleNature communications2026
Haldane's law works through X:Autosome incompatibility in Caenorhabditis briggsae/C. nigoni hybrids.
Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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1 citing paper in PubMed.
- Origins of Self-Fertility in ThreeBiology · 2026Review
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4 authors.
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Abstract
More than one hundred years ago, JBS Haldane noted that in a cross between two species, if one of the sexes is absent, rare or sterile, the affected sex is heterogametic. The underlying genetic causes for this phenomenon have been a source of debate ever since. Here, we test how Haldane's rule operates in Caenorhabditis nematodes by studying (1) crosses involving sex-determination mutants of two hybridizing species, and (2) crosses involving tetraploids. Our results indicate that the critical feature underlying Haldane's rule is incompatibility between a sex chromosome derived from only one species, and autosome pairs derived from both. In addition, we show that the mechanisms for evaluating the X:Autosome ratio have diverged during recent nematode evolution. We conclude that the way interactions between sex chromosomes and autosomes are structured causes them to play an important role in establishing genetic barriers between newly separating species.
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