Evidence map›Paper›PMID 41530121›Full record

ArticleNature communications2026

Intelectin-2 is a broad-spectrum antimicrobial lectin.

Amanda E Dugan, Deepsing Syangtan, Eric B Nonnecke, Rajeev S Chorghade, Amanda L Peiffer, Jenny J Yao, Jessica Ille-Bunn, Dallis Sergio, Gleb Pishchany, Catherine Dhennezel and 13 more

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In one paragraph

Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

23 authors.

Amanda E Dugan *Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA, USA.
Deepsing Syangtan *Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA, USA.ORCID http://orcid.org/0000-0001-5245-4782
Eric B NonneckeDepartment of Microbiology and Immunology, School of Medicine, University of California-Davis, Davis, CA, USA.ORCID http://orcid.org/0000-0001-5345-2009
Rajeev S ChorghadeDepartment of Chemistry, Massachusetts Institute of Technology, Cambridge, MA, USA.
Amanda L PeifferDepartment of Chemistry, Massachusetts Institute of Technology, Cambridge, MA, USA.ORCID http://orcid.org/0000-0001-8113-9458
Jenny J YaoDepartment of Chemistry, Massachusetts Institute of Technology, Cambridge, MA, USA.
Jessica Ille-BunnDepartment of Chemistry, Massachusetts Institute of Technology, Cambridge, MA, USA.
Dallis SergioThe Broad Institute of MIT and Harvard, Cambridge, MA, USA.ORCID http://orcid.org/0000-0001-9290-7088
Gleb PishchanyThe Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Catherine DhennezelThe Broad Institute of MIT and Harvard, Cambridge, MA, USA.ORCID http://orcid.org/0000-0003-3273-7165
Hera VlamakisThe Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Sunhee BaeDepartment of Chemistry, Massachusetts Institute of Technology, Cambridge, MA, USA.
Sheila JohnsonDepartment of Biochemistry, University of Wisconsin-Madison, Madison, WI, USA.
Chariesse EllisDepartment of Biochemistry, University of Wisconsin-Madison, Madison, WI, USA.
Soumi GhoshDepartment of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA.
Jill W AltyDepartment of Chemistry, Massachusetts Institute of Technology, Cambridge, MA, USA.
Carolyn E BarnesDepartment of Chemistry, Massachusetts Institute of Technology, Cambridge, MA, USA.
Miri KrupkinDepartment of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.ORCID http://orcid.org/0000-0002-5917-0894
Gerardo Cárcamo-OyarceDepartment of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.ORCID http://orcid.org/0000-0001-8324-6900
Katharina RibbeckDepartment of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.ORCID http://orcid.org/0000-0001-8260-338X
Ramnik J XavierThe Broad Institute of MIT and Harvard, Cambridge, MA, USA.ORCID http://orcid.org/0000-0002-5630-5167
Charles L BevinsDepartment of Microbiology and Immunology, School of Medicine, University of California-Davis, Davis, CA, USA.ORCID http://orcid.org/0000-0003-2725-2622
Laura L KiesslingDepartment of Chemistry, Massachusetts Institute of Technology, Cambridge, MA, USA. kiesslin@mit.edu.ORCID http://orcid.org/0000-0001-6829-1500

Funding

Medical Scientist Training ProgramT32GM007753 · NIGMS · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI WALENSKY, LOREN DAVID · 1985 to 2021
$50.0M
Pilot & Feasibility ProgramP30DK043351 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI Ramnik J Xavier · 1991 to 2026
$35.3M
Medical Scientist Training ProgramT32GM144273 · NIGMS · HARVARD MEDICAL SCHOOL · PI David Shumway Jones, Jacqueline A. Lees · 2022 to 2026
$14.7M
Universite de Montreal IBD Genetics Research CenterU01DK062432 · NIDDK · WHITEHEAD INSTITUTE FOR BIOMEDICAL RES · PI John D. Rioux · 2002 to 2026
$9.6M
Spatial and temporal resolution to dissect cellular circuits controlling intestinal physiology, immunity, and inflammatory pathologiesRC2DK135492 · NIDDK · BROAD INSTITUTE, INC. · PI Caroline Uhler, Ramnik J Xavier · 2023 to 2026
$7.9M
Synthetic Ligands for Modulating Immune Cell ResponsesR01AI055258 · NIAID · UNIVERSITY OF WISCONSIN-MADISON · PI KIESSLING, LAURA L · 2003 to 2024
$7.8M
Determinants of inception of inflammation in inflammatory bowel diseasesR01DK127171 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI ANANTHAKRISHNAN, ASHWIN N, XAVIER, RAMNIK J · 2021 to 2025
$5.4M
Identification and Characterization of Microbial Metabolites in ImmunityR01AI172147 · NIAID · BROAD INSTITUTE, INC. · PI Daniel Bartholomew Graham, Ramnik J Xavier · 2022 to 2026
$3.9M
Novel Defensins in Human Epithelial TissuesR37AI032738 · NIAID · UNIVERSITY OF CALIFORNIA AT DAVIS · PI BEVINS, CHARLES L · 2015 to 2022
$3.1M
Novel Defensins of Human EpitheliaR01AI032738 · NIAID · UNIVERSITY OF CALIFORNIA DAVIS · PI BEVINS, CHARLES L · 1993 to 2009
$2.3M
Development of multifunctional probes for profiling microbial glycansU01CA231079 · NCI · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI IMPERIALI, BARBARA, KIESSLING, LAURA L · 2018 to 2020
$1.4M
New mouse models to investigate host-microbe dynamics in physiology and innate immunityR21AI176012 · NIAID · UNIVERSITY OF CALIFORNIA AT DAVIS · PI BEVINS, CHARLES L · 2024 to 2025
$436k
NCI NIH HHS U01 CA231079NIAID NIH HHS R01 AI032738NIAID NIH HHS R01 AI055258NIAID NIH HHS R01 AI172147NIAID NIH HHS R21 AI176012NIAID NIH HHS R37 AI032738NIDDK NIH HHS P30 DK043351NIDDK NIH HHS R01 DK127171NIDDK NIH HHS RC2 DK135492NIDDK NIH HHS U01 DK062432NIGMS NIH HHS T32 GM007753NIGMS NIH HHS T32 GM144273NSF | Directorate for Biological Sciences (BIO) ICB-2024-BEM-10NSF | Directorate for Biological Sciences (BIO) NSF EF-2125118U.S. Department of Health & Human Services | NIH | National Cancer Institute (NCI) CA231079U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases (NIAID) AI125926U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases (NIAID) AI172147U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases (NIAID) AI176012U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases (NIAID) AI32738U.S. Department of Health & Human Services | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (National Institute of Diabetes & Digestive & Kidney Diseases) DK043351U.S. Department of Health & Human Services | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (National Institute of Diabetes & Digestive & Kidney Diseases) DK127171U.S. Department of Health & Human Services | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (National Institute of Diabetes & Digestive & Kidney Diseases) DK135492
6 · The paper itself

Abstract

Mammals regulate the localization, composition, and activity of their native microbiota at colonization sites. Lectins residing at these sites influence microbial populations, but their functional roles are often unclear. Intelectins are found in chordates at mucosal barriers, but their functions are not well characterized. In this study, we find that mouse intelectin-2 (mItln2) and human intelectin-2 (hItln2) engage and crosslink mucins via carbohydrate recognition. Moreover, both lectins recognize microbes within native microbial communities, including gram-positive and gram-negative isolates from the respiratory and gastrointestinal tracts. This ability to engage mammalian and microbial glycans arises from calcium-coordinated binding of carbohydrate residues within mucus and microbial surfaces. Microbes, but not human cells, bound by mItln2 or hItln2, suffer a loss of viability. These findings underscore the crucial antimicrobial role of mammalian intelectin-2 in mucosal defense, where it plays offensive (microbial killing) and defensive (mucus crosslinking) roles in regulating microbial colonization.

Indexed as

Anti-Infective AgentsLectinsAnimalsHumansMiceMice, Inbred C57BLMucinsPolysaccharidesAnti-Infective AgentsLectinsMucinsPolysaccharides

Identifiers

PMID41530121
PMCPMC12800186

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.