ArticleCanadian journal of ophthalmology. Journal canadien d'ophtalmologie2026
Loss to follow-up and increase in cup-to-disc ratio among glaucoma patients in the IRIS Registry.
Article in Canadian journal of ophthalmology. Journal canadien d'ophtalmologie, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Special Issue: Molecular Mechanisms and Treatment of Retinal Diseases.International journal of molecular sciences · 2026Article
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Authors and funding
5 authors.
Funding
Abstract
objectiveTo assess the association between loss to follow-up (LTFU) and risk of increase in cup-to-disc ratio (CDR) among a national registry cohort of patients with primary open-angle glaucoma (POAG).
designA retrospective longitudinal cohort study.
participantsPatients who had a POAG diagnosis in 2014 and had CDR documented in the IRIS Registry (Intelligent Research in Sight) both in 2014 and 2019.
methodsLTFU was defined as a calendar year or more without an encounter. Log-Poisson regression models were used to estimate the relative risk (RR) and 95% confidence intervals (CIs) for the increase in CDR. A sensitivity analysis was also conducted to address ceiling effects for patients with baseline CDR ≥0.8.
main outcome measuresAn increase by ≥0.2 in CDR from 2014 to 2019.
resultsAmong 208,517 patients, 6.9% had an increase by ≥0.2 in CDR from 2014 to 2019. While most patients (81.6%) maintained follow-up every year, 16.1% were LTFU for 1-2 years, and 2.3% were LTFU for 3-4 years. A lapse of 3-4 years was associated with a 15% higher risk of increase in CDR (adjusted RR [aRR] = 1.15, 95% CI: 1.00-1.32) compared to no lapse in care after accounting for age, sex, race, insurance, smoking status, glaucoma severity, baseline intraocular pressure (IOP), and baseline CDR. For patients with CDR ≥ 0.8 at baseline, risk of increase in CDR by ≥0.05 was also associated with LTFU (aRR = 1.34, 95% CI: 1.11-1.60; lapse of 3-4 years compared to no lapse).
conclusionsLTFU is an independent risk factor for an increase in CDR among patients with POAG.
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