Evidence map›Paper›PMID 41529685›Full record

ArticleCell reports methods2026

Evaluation of the effects of a new standard equation for doubly labeled water studies.

Kaja Falkenhain, Jennifer C Rood, Corby K Martin, Peter T Katzmarzyk, Eric Ravussin, George A Bray, Diana M Thomas, Robert J Baxter, Leanne M Redman

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell reports methods, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Trial
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Kaja FalkenhainPennington Biomedical Research Center, Louisiana State University, Baton Rouge, LA 70808, USA.
Jennifer C RoodPennington Biomedical Research Center, Louisiana State University, Baton Rouge, LA 70808, USA.
Corby K MartinPennington Biomedical Research Center, Louisiana State University, Baton Rouge, LA 70808, USA.
Peter T KatzmarzykPennington Biomedical Research Center, Louisiana State University, Baton Rouge, LA 70808, USA.
Eric RavussinPennington Biomedical Research Center, Louisiana State University, Baton Rouge, LA 70808, USA.
George A BrayPennington Biomedical Research Center, Louisiana State University, Baton Rouge, LA 70808, USA.
Diana M ThomasDepartment of Mathematical Sciences, US Military Academy, West Point, NY 10996, USA.
Robert J BaxterDepartment of Mathematical Sciences, US Military Academy, West Point, NY 10996, USA.
Leanne M RedmanPennington Biomedical Research Center, Louisiana State University, Baton Rouge, LA 70808, USA. Electronic address: leanne.redman@pbrc.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Accurate measurement of energy expenditure is critical for metabolic research and public health. Doubly labeled water (DLW) is the gold standard for assessing free-living energy expenditure, yet inconsistencies in equations impede comparability across studies. This analysis evaluates a newly proposed standardized equation of energy expenditure from the DLW method against commonly employed historical equations. Using validation data from whole-room indirect calorimetry, we demonstrate that the new equation offers improved accuracy. Further, analysis of a large historical dataset and mathematical modeling revealed a systematic bias of ∼1.6%, indicative of an underestimation of energy expenditure estimates with the new equation compared to previous equations. Application of a newly developed correction factor mitigated this bias, allowing for closer alignment between equations. These findings support adoption of the new standard equation and offer a corrective approach for harmonizing data, thereby facilitating methodological consistency in DLW studies and allowing for the preservation of the utility of historical datasets.

Indexed as

Calorimetry, IndirectEnergy MetabolismWaterDeuteriumHumansOxygen IsotopesDeuteriumOxygen IsotopesWatercalorimetryCP: metabolismdoubly labeled waterenergy expendituremetabolismstandardization

Identifiers

PMID41529685
PMCPMC12853185

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.