SynthesisJournal of neonatal-perinatal medicine2026
Association of anemia and necrotizing enterocolitis in neonates: Systematic review and meta-analysis of transfusion thresholds, erythropoietin trials, and observational studies.
Synthesis in Journal of neonatal-perinatal medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Emerging evidence on the safety of enteral feeding during PRBC transfusion in preterm infants.Pediatric research · 2026Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
BackgroundMeta-analyses of observational studies evaluating association between blood transfusion and necrotizing enterocolitis (NEC) have shown mixed results and an independent association between anemia and NEC requires further evaluation.ObjectiveTo investigate the association of NEC with anemia in preterm infants via meta-analysis of (1) randomized controlled trials (RCTs) evaluating transfusion thresholds and recombinant erythropoietin (rEpo)/darbepoetin and (2) case-control studies comparing hematocrit levels between NEC cases and controls.Data sourcesPubMed, Embase, Scopus, and the Cochrane Database were searched in August 2025, and the results were supplemented by other sources.Study selection(1) Transfusion threshold and rEpo RCTs evaluating NEC rates in preterm infants with lower hemoglobin (Hb) levels compared with higher Hb levels. (2) Case-control studies comparing hematocrit levels between NEC cases and controls.Primary outcomeThe incidence of any stage NEC in infants with low versus high Hb group.ResultsRCTs evaluating transfusion threshold (n = 4, 3307 participants) showed no difference in NEC incidence between the low versus high Hb group [OR: 1.14 (CI: 0.89, 1.46),
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