Evidence map›Paper›PMID 41529034›Full record

Trial reportPloS one2026

The effects of vaginal gel from Myrtus communis on the sexual function of married women during reproductive aging: A study protocol for a randomized controlled trial.

Bahareh Khajehpour, Raheleh Babazadeh, Roshanak Salari, Jamshid Jamali, Malihe Mahmoudinia

Abstract readRandomized Controlled Trial
In one paragraph

Trial report in PloS one, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Bahareh KhajehpourMSc Student of Midwifery, Faculty of Nursing and Midwifery, Mashhad University of Medical Sciences, Mashhad, Iran.ORCID https://orcid.org/0000-0002-8455-4240
Raheleh BabazadehNursing and Midwifery Care Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.ORCID https://orcid.org/0000-0001-6323-7249
Roshanak SalariAssociate Professor of Drug Control, Department of Pharmaceutical Sciences in Persian Medicine, School of Persian and Complementary Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Jamshid JamaliAssociate Professor of Biostatistics, Department of Biostatistics, School of Health, Mashhad University of Medical Sciences, Mashhad, Iran.
Malihe MahmoudiniaDepartment of Obstetrics and Gynecology, Faculty of Medicine, Maryland, Associate Professor of Obstetrics & Gynecology, Fellowship of infertility, Mashhad University of Medical Sciences, Mashhad, Iran.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionHuman sexuality is an important aspect of functionality, and many patients believe that it determines their quality of life. Sexual dysfunction can lead to stress, strained relationships, and a decrease in self-esteem. The majority of modern medical treatments for improving female sexual function are associated with significant side effects and high costs. Traditionally, M. communis has been used to treat sexual impotence. Here, we present the protocol of an interventional clinical phase II study to test the hypothesis that vaginal gel containing Myrtus communis extract can improve sexual function in women of reproductive age. METHODS/

designIn a prospective, randomized, placebo-controlled and highly blind clinical phase II trial, 80 women aged 18--40 years with sexual dysfunction meeting the inclusion criteria will be randomized to an intervention group receiving a vaginal gel containing myrtle leaf extract (n = 38) or an active control group receiving a placebo gel with an identical appearance (n = 38). Randomization will be performed via a permuted block technique with random allocation software. This study will be conducted at the women's clinic of Imam Reza Hospital in Mashhad. Blinded assessments of outcome variables will be conducted twice: before treatment and one month after treatment. The primary outcome measure was sexual function. DISCUSSION: This randomized controlled clinical trial evaluates the efficacy of the vaginal gel Myrtus communis on the sexual function of married women during reproductive age. The study design presented here fulfills the criteria of a high-quality clinical phase II trial of sexual function.

trial registrationIRCT.behdasht.gov.ir Identifier: IRCT20230723058892N1.

Indexed as

AgingMyrtusPlant ExtractsSexual Dysfunction, PhysiologicalVaginal Creams, Foams, and JelliesAdolescentAdultFemaleHumansMarriageProspective StudiesQuality of LifeSexual BehaviorYoung AdultPlant ExtractsVaginal Creams, Foams, and Jellies

Identifiers

PMID41529034
PMCPMC12798978

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.