Evidence map›Paper›PMID 41528972›Full record

ArticlePloS one2026

Melatonin alleviates chronic intermittent hypoxia-induced gastric mucosal injury via attenuation of oxidative stress and JNK-mediated apoptotic signaling in rats.

Hong L Ji, Hua L Yu, Jia F Luo, Xin R Li, Cheng X Nie, Tie J Liu, Huan H Jiang, Cong H Liu, Jia B Zhang, Xin H Yuan and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Hong L JiNorth China University of Science and Technology School of Clinical Medicine, Tangshan, Hebei, China.ORCID https://orcid.org/0009-0005-8573-9887
Hua L YuDepartment of Respiratory Medicine, North China University of Science and Technology Affiliated Hospital, Tangshan, Hebei, China.
Jia F LuoNorth China University of Science and Technology School of Clinical Medicine, Tangshan, Hebei, China.
Xin R LiNorth China University of Science and Technology School of Clinical Medicine, Tangshan, Hebei, China.
Cheng X NieNorth China University of Science and Technology School of Clinical Medicine, Tangshan, Hebei, China.
Tie J LiuDepartment of Anesthesiology, North China University of Science and Technology Affiliated Hospital, Tangshan, Hebei, China.
Huan H JiangDepartment of Pharmacy, North China University of Science and Technology Affiliated Hospital, Tangshan, Hebei, China.
Cong H LiuDepartment of Endocrinology, North China University of Science and Technology Affiliated Hospital, Tangshan, Hebei, China.
Jia B ZhangDepartment of Respiratory Medicine, North China University of Science and Technology Affiliated Hospital, Tangshan, Hebei, China.
Xin H YuanDepartment of Respiratory Medicine, North China University of Science and Technology Affiliated Hospital, Tangshan, Hebei, China.
Xiao F SongDepartment of Otolaryngology, Hebei Provincial People's Hospital, Shijiazhuang, Hebei, China.
Yue D LiDepartment of Anesthesiology, North China University of Science and Technology Affiliated Hospital, Tangshan, Hebei, China.
Yanlei GeDepartment of Respiratory Medicine, North China University of Science and Technology Affiliated Hospital, Tangshan, Hebei, China.ORCID https://orcid.org/0000-0002-4282-9795
Ai S FuDepartment of Respiratory Medicine, North China University of Science and Technology Affiliated Hospital, Tangshan, Hebei, China.ORCID https://orcid.org/0009-0001-7373-6401

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundTo investigate the mechanism of chronic intermittent hypoxia on gastric injury in rats and the intervening effect and possible mechanism of melatonin.

methodsForty-eight male Wistar rats were randomly divided into normal control, intermittent hypoxia, and melatonin treatment groups. Subgroups (n = 4 per time point) were treated for 2, 4, 6, and 8 weeks. Gastric tissue morphology, gastric juice pH, pepsin levels, oxidative stress markers (MDA and SOD), and the expression of JNK and apoptosis-related genes (Bax, Bcl-2) were assessed.

resultsThe intermittent hypoxia group exhibited significant gastric mucosal damage, decreased pH, increased pepsin, elevated MDA, reduced SOD, and upregulation of JNK and Bax/Bcl-2 mRNA ratio. Melatonin treatment markedly alleviated these pathological and molecular changes compared to the intermittent hypoxia group (P < 0.05).

conclusionChronic intermittent hypoxia induces gastric mucosal injury, which is associated with oxidative stress imbalance and activation of JNK-mediated apoptotic signaling. Melatonin exerts a protective effect by enhancing antioxidant capacity and suppressing the JNK-Bax/Bcl-2 pathway.

Indexed as

ApoptosisGastric MucosaHypoxiaMAP Kinase Signaling SystemMelatoninOxidative StressAnimalsAntioxidantsbcl-2-Associated X ProteinJNK Mitogen-Activated Protein KinasesMaleProto-Oncogene Proteins c-bcl-2RatsRats, WistarSignal TransductionAntioxidantsbcl-2-Associated X ProteinJNK Mitogen-Activated Protein KinasesMelatoninProto-Oncogene Proteins c-bcl-2

Identifiers

PMID41528972
PMCPMC12799010

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.