Evidence map›Paper›PMID 41528653›Full record

ArticleJournal of materials science. Materials in medicine2026

Antimicrobial activity of a short guanidine mimic immobilised on contact lenses.

Manjulatha Sara, Rajesh Kuppusamy, George Enninful, Dittu Suresh, Krasimir Vasilev, David Mackenzie, Farida Dehghani, Alex Hui, Edgar H H Wong, Muhammad Yasir and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of materials science. Materials in medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Manjulatha SaraSchool of Optometry and Vision Science, UNSW Sydney, Sydney, Australia. manjulatha.sara@unsw.edu.au.
Rajesh KuppusamyWhiteley Corporation, Tomago, Newcastle, NSW, 2322, Australia.
George EnninfulSchool of Optometry and Vision Science, UNSW Sydney, Sydney, Australia.
Dittu SureshSchool of Chemistry, UNSW Sydney, Sydney, Australia.
Krasimir VasilevBiomedical Nanoengineering Laboratory, College of Medicine and Public Health, Flinders University, Bedford Park, SA, 5042, Australia.
David MackenzieSchool of Physics, University of Sydney, Sydney, NSW, 2006, Australia.
Farida DehghaniSchool of Chemical and Biomolecular Engineering, University of Sydney, Sydney, Australia.
Alex HuiSchool of Optometry and Vision Science, UNSW Sydney, Sydney, Australia.
Edgar H H WongSchool of Optometry and Vision Science, UNSW Sydney, Sydney, Australia.
Muhammad YasirSchool of Optometry and Vision Science, UNSW Sydney, Sydney, Australia.
Naresh KumarSchool of Chemistry, UNSW Sydney, Sydney, Australia.
Mark WillcoxSchool of Optometry and Vision Science, UNSW Sydney, Sydney, Australia.

Funding

National Health and Medical Research Council APP1183597
6 · The paper itself

Abstract

The advancement of antimicrobial contact lenses presents a promising strategy for mitigating microbial keratitis. This study investigated the antimicrobial activity of four guanidine-substituted anthranilic amide peptidomimetics (GAMPs), identifying RK1083 as the most potent candidate. The minimum inhibitory concentrations ranged from 20 to 86 µM, with therapeutic indices between 2 and 22. All tested GAMPs exhibited resistance to proteolytic degradation. RK1083 was covalently immobilized onto contact lenses using carbodiimide chemistry, oxazoline plasma deposition, and plasma immersion ion implantation (PIII). The modified lenses demonstrated increased nitrogen content (≥3%), changes in surface charge, and improved hydrophilicity. Adhesion of Staphylococcus aureus was reduced by 5 log₁₀, while Pseudomonas aeruginosa adhesion decreased by ≥5 log₁₀ on oxazoline and PIII-treated lenses, and by ≥3 log₁₀ on carbodiimide-treated lenses. RK1083-coated surfaces exhibited no cytotoxicity toward corneal epithelial cells, and carbodiimide-treated lenses maintained antimicrobial activity post-sterilization. These results underscore RK1083's potential for enhancing antimicrobial contact lens surfaces with improved bacterial resistance.

Indexed as

Anti-Infective AgentsContact LensesGuanidinePeptidomimeticsBacterial AdhesionCarbodiimidesHumansKeratitisMicrobial Sensitivity TestsPseudomonas aeruginosaStaphylococcus aureusSurface PropertiesAnti-Infective AgentsCarbodiimidesGuanidinePeptidomimeticsantimicrobial peptoidsContact lenscovalent attachmentmicrobial keratitisP. aeruginosa.

Identifiers

PMID41528653
PMCPMC12804252

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.