ArticleChild's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery2026
Dynamic monitoring of LC3 and GPX4 in children with severe craniocerebral injury during perioperative period and its relationship with prognosis.
Article in Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo investigate the dynamic changes of microtubule-associated protein 1 light chain 3 (LC3) and glutathione peroxidase 4 (GPX4) during the perioperative period in pediatric patients with severe traumatic brain injury (sTBI) and their association with prognosis.
methodsA prospective cohort of 120 pediatric sTBI patients admitted to our Hospital from May 2022 to October 2024 was enrolled. All patients underwent traumatic brain injury surgery. Based on their 6-month postoperative outcomes, they were categorized into either the favorable prognosis group or the poor prognosis group. Propensity score matching (PSM) was employed to minimize confounding bias. Perioperative LC3 and GPX4 levels were compared between the two groups to analyze their relationship with prognosis. Receiver operating characteristic (ROC) curve analysis was performed to evaluate the predictive value of LC3 and GPX4 for prognosis in sTBI patients.
resultsAmong the 120 sTBI patients, 50 (41.67%) had poor prognosis and were assigned to the poor prognosis group, while the remaining 70 were included in the favorable prognosis group. At admission, the poor prognosis group exhibited lower Glasgow Coma Scale (GCS) scores and albumin levels but higher intracranial pressure and activated partial thromboplastin time (APTT) compared to the favorable prognosis group (P < 0.05). To control for confounding bias, PSM was applied, resulting in 74 successfully matched cases (37 per group). Post-matching univariate analysis confirmed balanced baseline covariates (P > 0.05). Compared to preoperative levels, both groups showed decreased LC3 and increased GPX4 levels postoperatively (P < 0.05). The poor prognosis group demonstrated higher serum LC3 levels and lower GPX4 levels at postoperative days 1, 3, and 7 compared to the favorable prognosis group (P < 0.05). ROC analysis revealed that the area under the curve (AUC) values for serum LC3 and GPX4 in predicting prognosis at postoperative days 1, 3, and 7 all exceeded 0.7, with AUC values increasing significantly over time. The combined predictive AUC values of LC3 and GPX4 at different time points were greater than those of either biomarker alone.
conclusionSerum LC3 levels exhibited a declining trend, whereas GPX4 levels increased postoperatively in pediatric sTBI patients. Both biomarkers were closely associated with prognosis and may serve as potential indicators for early clinical identification of high-risk patients and precision intervention.
Indexed as
Identifiers
41528530What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.