Evidence map›Paper›PMID 41528511›Full record

ArticleMikrochimica acta2026

Dual-signal histamine aptasensor design based on SERS and electrochemical effects of gold nanomaterials.

Yi Chen, Xueying Gao, Yue Pan, Muxi Zhang, Zhouping Wang, Xiaoyuan Ma

Abstract read
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Article in Mikrochimica acta, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

6 authors.

Yi ChenState Key Laboratory of Food Science and Resourse, Jiangnan University, Wuxi, 214122, China.
Xueying GaoState Key Laboratory of Food Science and Resourse, Jiangnan University, Wuxi, 214122, China.
Yue PanState Key Laboratory of Food Science and Resourse, Jiangnan University, Wuxi, 214122, China.
Muxi ZhangSchool of Science, Xi'an Jiaotong-Liverpool University, Suzhou, 215123, China.
Zhouping WangState Key Laboratory of Food Science and Resourse, Jiangnan University, Wuxi, 214122, China.
Xiaoyuan MaState Key Laboratory of Food Science and Resourse, Jiangnan University, Wuxi, 214122, China. maxy@jiangnan.edu.cn.

Funding

Jiangsu Agriculture Science and Technology Innovation Fund CX(23)3045National Natural Science Foundation of China 32372422
6 · The paper itself

Abstract

A dual signal (Raman/electrochemical) and selective assay for determination of histamine (HA) was developed by leveraging the surface-enhanced Raman and electrochemical enhancement effects of gold nanomaterials and the high specificity of aptamers. Gold nanorods probes co-modified with the Raman reporter molecule 4-MBA and HA aptamers were prepared. Simultaneously, gold nanoparticles were electrodeposited onto ITO, and complementary DNA strands were immobilized to form an electrochemical signal substrate. The two parts assembled based on complementary base pairing. With the addition of HA, aptamers preferentially combined to HA and the assembly disrupted, leading to synchronous decreases in Raman and electrochemical signals. The results demonstrated a linear relationship between the logarithmic values of HA concentration (0.1-1000 mg/L) and the dual signals, with a detection limit as low as 0.015 mg/L. Furthermore, its application in fish yielded satisfactory spiked recoveries (92.6%-94.5%), confirming its reliability in real food analysis. The method not only enhances detection reliability and anti-interference capabilities but also enables precise identification of trace HA. Potential applications of the method extend beyond HA detection, offering a versatile platform for food safety monitoring and public health protection.

Indexed as

Aptamers, NucleotideBiosensing TechniquesElectrochemical TechniquesGoldHistamineMetal NanoparticlesAnimalsFishesLimit of DetectionSpectrum Analysis, RamanAptamers, NucleotideGoldHistamineAptasensorElectrochemical detectionGold nanomaterialsHistamineSurface-enhanced raman scattering

Identifiers

PMID41528511

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.