ArticleGraefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie2026
Factors influencing the long-term-success of the XEN gel stent.
Article in Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Preserflo MicroShunt Outcomes in Rare and Refractory Glaucoma Entities Compared with Matched Primary Open-Angle Glaucoma Controls: A Retrospective Exploratory Study.Clinical ophthalmology (Auckland, N.Z.) · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThe XEN gel stent is a minimally invasive surgical device for patients with open-angle glaucoma, developed to reduce complications associated with traditional filtration surgery. This study aimed to identify clinical factors that influence long-term surgical success, particularly in the context of postoperative conjunctival scarring.
methodsIn this retrospective study, 773 eyes of patients with glaucoma treated at a tertiary care center underwent implantation of the XEN gel stent. The primary outcome was long-term surgical success, defined as a reduction in intraocular pressure of at least 20% and achieving a target pressure of 18, 15, or 12 mmHg, either without (complete) or with (qualified) medication. Secondary outcomes included intraocular pressure reduction, change in best-corrected visual acuity and medication use. Potential risk factors were analysed using Kaplan-Meier survival curves and multivariable Cox regression.
resultsAt 24 months, complete and qualified success for a target pressure of 18 mmHg was achieved in 50% and 64% of cases, respectively; at 72 months, in 35% and 54%. Visual acuity remained stable. Female sex, mitomycin C dose, moderately elevated baseline pressure, and lower pressure on the first postoperative day were associated with significantly higher success rates (p < 0.05). Glaucoma subtype and previous incisional glaucoma surgery had no significant effect.
conclusionSex, lower antimetabolite dose and intraocular pressure values before and shortly after surgery are significant predictors of long-term success following XEN gel stent implantation.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.