Evidence map›Paper›PMID 41528468›Full record

ArticleGraefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie2026

Petrolatum-based ointment application induces swelling of the PRESERFLO Microshunt.

Ryo Tomita, Taiga Inooka, Takato Kajita, Hideyuki Shimizu, Ayana Suzumura, Jun Takeuchi, Tsuyoshi Matsuno, Hidekazu Inami, Koji M Nishiguchi, Atsushi Noro and 1 more

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Ryo Tomita *Department of Ophthalmology, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya, 466-8550, Aichi, Japan.
Taiga Inooka *Department of Ophthalmology, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya, 466-8550, Aichi, Japan.
Takato KajitaDepartment of Molecular & Macromolecular Chemistry, Graduate School of Engineering, Nagoya University, Nagoya, 464-8603, Aichi, Japan.
Hideyuki ShimizuDepartment of Ophthalmology, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya, 466-8550, Aichi, Japan.
Ayana SuzumuraDepartment of Ophthalmology, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya, 466-8550, Aichi, Japan.
Jun TakeuchiDepartment of Ophthalmology, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya, 466-8550, Aichi, Japan.
Tsuyoshi MatsunoDepartment of Ophthalmology, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya, 466-8550, Aichi, Japan.
Hidekazu InamiDepartment of Ophthalmology, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya, 466-8550, Aichi, Japan.
Koji M NishiguchiDepartment of Ophthalmology, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya, 466-8550, Aichi, Japan.
Atsushi Noro *Department of Molecular & Macromolecular Chemistry, Graduate School of Engineering, Nagoya University, Nagoya, 464-8603, Aichi, Japan. noro@nagoya-u.jp.
Kenya Yuki *Department of Ophthalmology, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya, 466-8550, Aichi, Japan. yukikenya@med.nagoya-u.ac.jp.

Funding

Japan Society for the Promotion of Science 21K16870
6 · The paper itself

Abstract

purposeTo report the clinical cases of PRESERFLO MicroShunt swelling following exposure to petrolatum-based ophthalmic ointment and to experimentally identify the cause and composition of the swollen MicroShunt.

methodsA retrospective case series and an in vitro experimental study were conducted. The clinical series included three glaucoma patients with swollen MicroShunts after ointment exposure and four patients whose explanted MicroShunts showed no swelling without ointment exposure. In vitro experiments were performed using unused MicroShunts incubated in 0.3% ofloxacin ophthalmic ointment. A time-course immersion study was conducted for 24 h at room temperature, with microscopy documenting dimensional changes. After 24 h and 3 months, swollen devices underwent quantitative analysis using proton nuclear magnetic resonance (

resultsAll three MicroShunts exposed to ointment exhibited marked swelling, whereas those without exposure showed no swelling. In vitro, ointment-exposed devices displayed similar swelling, became friable, and fractured after 24 h. Dimensional analysis demonstrated progressive increases, with outer diameter expanding 1.44-fold and fin width 1.29-fold by 24 h.

conclusionsDirect contact between petrolatum-based ophthalmic ointment and the SIBS-based MicroShunt induced markedly, time-dependent swelling that compromises the its structural integrity. Thus, the use of ophthalmic ointment should be avoided in patients with an exposed MicroShunt.

Indexed as

GlaucomaIntraocular PressurePetrolatumFemaleHumansOintmentsRetrospective StudiesOintmentsPetrolatumBleb leakGlaucomaOphthalmic ointmentPRESERFLO microshunt

Identifiers

PMID41528468
PMCPMC13091893

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.