Evidence map›Paper›PMID 41528423›Full record

ArticleClinical journal of gastroenterology2026

Primary splenic angiosarcoma with diffuse intrasinusoidal hepatic metastasis mimicking lymphoma: a diagnostic challenge.

Tomoko Saito, Mie Arakawa, Miyu Osaki, Tomoko Tokumaru, Takuro Uchida, Masao Iwao, Mizuki Endo, Yuzo Oyama, Masaaki Kodama, Kazuhiro Mizukami

Abstract readCase Reports
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In one paragraph

Article in Clinical journal of gastroenterology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Tomoko SaitoDepartment of Gastroenterology, Oita University, Yufu, Japan. haraguchi@oita-u.ac.jp.ORCID http://orcid.org/0000-0002-9445-3048
Mie ArakawaDepartment of Gastroenterology, Oita University, Yufu, Japan.
Miyu OsakiDepartment of Gastroenterology, Oita University, Yufu, Japan.
Tomoko TokumaruDepartment of Gastroenterology, Oita University, Yufu, Japan.
Takuro UchidaDepartment of Gastroenterology, Oita University, Yufu, Japan.
Masao IwaoDepartment of Gastroenterology, Oita University, Yufu, Japan.
Mizuki EndoDepartment of Gastroenterology, Oita University, Yufu, Japan.
Yuzo OyamaDepartment of Diagnostic Pathology, Oita University, Yufu, Japan.
Masaaki KodamaDepartment of Gastroenterology, Oita University, Yufu, Japan.
Kazuhiro MizukamiDepartment of Gastroenterology, Oita University, Yufu, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPrimary splenic angiosarcoma is a rare aggressive vascular neoplasm. Although hepatic metastases are common, diffuse intrasinusoidal hepatic involvement is extremely rare and poses a significant diagnostic challenge. CASE REPORT: A 60-year-old woman presented with bilateral lower extremity edema, hypoalbuminemia, and thrombocytopenia. Contrast-enhanced computed tomography revealed marked splenomegaly, but no distinct hepatic lesions. Gadoxetic acid-enhanced magnetic resonance imaging revealed reduced hepatic uptake without focal abnormalities.

conclusionPrimary splenic angiosarcoma rarely presents with non-nodular intrasinusoidal hepatic metastasis, mimicking infiltrative liver diseases. Liver biopsy may fail to yield a definitive diagnosis. Therefore, a splenectomy may be required to establish a definitive diagnosis and guiding appropriate management when liver biopsy is inconclusive. Recognizing this uncommon metastatic pattern is crucial to avoid misdiagnosis and ensure timely treatment.

Indexed as

HemangiosarcomaLiver NeoplasmsLymphomaSplenic NeoplasmsDiagnosis, DifferentialFemaleHumansMiddle AgedPositron Emission Tomography Computed TomographySplenectomyIntrasinusoidal metastasisLiver biopsyPositron-emission tomography computed tomographyPrimary splenic angiosarcomaSplenectomy

Identifiers

PMID41528423

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.