Evidence map›Paper›PMID 41528413›Full record

ArticleProgress in orthodontics2026

Ferroptosis inhibits cementoblast mineralization via cGAS-STING/GPX4 axis.

Tian Wei, Dongyang Li, Jie Zhang, Zhe Zhou, Chunmiao Jiang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Progress in orthodontics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Tian WeiThe Affiliated Hospital of Qingdao University, Qingdao, China.
Dongyang LiThe Affiliated Hospital of Qingdao University, Qingdao, China.
Jie ZhangThe Affiliated Hospital of Qingdao University, Qingdao, China.
Zhe ZhouThe Affiliated Hospital of Qingdao University, Qingdao, China.
Chunmiao JiangThe Affiliated Hospital of Qingdao University, Qingdao, China. jiangcm@qdu.edu.cn.

Funding

National Natural Science Foundation of China 82401066Natural Science Foundation of Shandong Province ZR2022MH215Natural Science Foundation of Shandong Province ZR2024QC169
6 · The paper itself

Abstract

backgroundTo explore the potential role of cGAS-STING/GPX4 axis-mediated ferroptosis in cementoblast mineralization under compressive force and to determine its involvement in orthodontically induced inflammatory external root resorption (OIIERR). METHODOLOGY: An immortalized murine cementoblast cell line (OCCM-30) was subjected to a 2 g/cm

resultsCompressive force significantly reduced RUNX2, OPN, OCN, and GPX4 expression, while increasing ROS, Fe

conclusionsCompressive force inhibits cementoblast mineralization by inducing ferroptosis via the cGAS-STING/GPX4 axis. Furthermore, H-151 effectively suppresses OIIERR in mice. Targeting cGAS-STING/GPX4 axis-mediated ferroptosis may serve as a potential therapeutic strategy for OIIERR treatment.

Indexed as

Calcification, PhysiologicFerroptosisMembrane ProteinsNucleotidyltransferasesPhospholipid Hydroperoxide Glutathione PeroxidaseAnimalsCell LinecGAS-STING Signaling PathwayCyclic Guanosine Monophosphate-Adenosine Monophosphate SynthaseMiceReactive Oxygen SpeciesSTING ProteincGAS protein, mouseCyclic Guanosine Monophosphate-Adenosine Monophosphate Synthaseglutathione peroxidase 4, mouseMembrane ProteinsNucleotidyltransferasesPhospholipid Hydroperoxide Glutathione PeroxidaseReactive Oxygen SpeciesSting1 protein, mouseSTING ProteinCementoblastcGAS-STINGFerroptosisMineralizationMitochondrial damageRoot resorption

Identifiers

PMID41528413
PMCPMC12799880

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.