Evidence map›Paper›PMID 41528386›Full record

ArticlePediatric surgery international2026

Is trisomy 21 a risk factor for postoperative complications after pediatric surgery for neonatal gastrointestinal disease? A retrospective study using a National Clinical Database in Japan.

Shotaro Matsudera, Daisuke Shinjo, Kan Suzuki, Kei Ogino, Shun Watanabe, Sumiko Irie, Takeshi Yamaguchi, Hisateru Tachimori, Shinji Morita, Masanobu Nakajima and 1 more

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Article in Pediatric surgery international, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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0cells of the map it votes in
1citing papers in PubMed
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1 · What the graph read from it

What it found

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2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

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4 · The record

Corrections and comments

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5 · Who and what money

Authors and funding

11 authors.

Shotaro MatsuderaDivision of Pediatric Surgery, Dokkyo Medical University Hospital, 880 Kitakobayashi, Mibu, Shimotsuga, Tochigi, 321-0293, Japan. matsu-s@dokkyomed.ac.jp.
Daisuke ShinjoDepartment of Health Policy and Informatics, Institute of Science Tokyo, Graduate School of Medical and Dental Science, S1651/S1568 M&D Tower1-5-45 Yushima, Bunkyo-ku, Tokyo, 113-8519, Japan.
Kan SuzukiDivision of Pediatric Surgery, Dokkyo Medical University Hospital, 880 Kitakobayashi, Mibu, Shimotsuga, Tochigi, 321-0293, Japan.
Kei OginoDivision of Pediatric Surgery, Dokkyo Medical University Hospital, 880 Kitakobayashi, Mibu, Shimotsuga, Tochigi, 321-0293, Japan.
Shun WatanabeDivision of Pediatric Surgery, Dokkyo Medical University Hospital, 880 Kitakobayashi, Mibu, Shimotsuga, Tochigi, 321-0293, Japan.
Sumiko IrieDivision of Pediatric Surgery, Dokkyo Medical University Hospital, 880 Kitakobayashi, Mibu, Shimotsuga, Tochigi, 321-0293, Japan.
Takeshi YamaguchiDivision of Pediatric Surgery, Dokkyo Medical University Hospital, 880 Kitakobayashi, Mibu, Shimotsuga, Tochigi, 321-0293, Japan.
Hisateru TachimoriDepartment of Health Policy and Management, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo, 160-8582, Japan.
Shinji MoritaDepartment of Surgical Oncology, Graduate School of Medicine, Dokkyo Medical University, 880 Kitakobayashi, Mibu, Shimotsuga, Tochigi, 321-0293, Japan.
Masanobu NakajimaDepartment of Surgical Oncology, Graduate School of Medicine, Dokkyo Medical University, 880 Kitakobayashi, Mibu, Shimotsuga, Tochigi, 321-0293, Japan.
Kazuyuki KojimaDepartment of Surgical Oncology, Graduate School of Medicine, Dokkyo Medical University, 880 Kitakobayashi, Mibu, Shimotsuga, Tochigi, 321-0293, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTrisomy 21 is associated with neonatal surgical disorders, such as duodenal atresia, Hirschsprung's disease, and anorectal malformation (ARM). Therefore, the purpose of this study was to compare postoperative complications in patients with vs. without trisomy 21 who underwent neonatal gastrointestinal surgery and to identify risk factors for postoperative complications after these surgeries in the Japanese population.

methodsFrom the National Clinical Database-Pediatric, we selected patients with duodenal atresia/stenosis, Hirschsprung's disease, and ARM operated in the neonatal period from 2016 to 2020 and analyzed the risk factors for postoperative complications.

resultsDuodenal atresia/stenosis, Hirschsprung's disease, and ARM were diagnosed in 4052 patients, of which 2486 patients were operated on in the neonatal period. These patients comprised 801 with duodenal atresia/stenosis, 289 with Hirschsprung's disease, and 1446 with ARM. The numbers of patients with complicated trisomy 21 were 212 (26.5%), 16 (5.5%), and 102 (7.1%) for duodenal atresia/stenosis, Hirschsprung's disease, and ARM, respectively. Regarding duodenal atresia/stenosis, multivariable logistic regression analysis showed that trisomy 21 were risk factors for postoperative complications.

conclusionIn this analysis of Japanese data, trisomy 21 was an independent risk factor for postoperative complications in patients with duodenal atresia/stenosis.

Indexed as

Anorectal MalformationsDigestive System Surgical ProceduresDown SyndromeGastrointestinal DiseasesPostoperative ComplicationsDatabases, FactualDuodenal ObstructionFemaleHirschsprung DiseaseHumansInfant, NewbornJapanMaleRetrospective StudiesRisk FactorsAnorectal malformationDuodenal atresia/StenosisHirschsprung’s diseaseTrisomy 21

Identifiers

PMID41528386

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.