ArticleCancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology2026
Association between Broad-Spectrum Antibiotic Use and Risk of Early-Onset Colorectal Cancer.
Article in Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Early-Onset Colorectal Cancer: From Epidemiologic Shift to Life-Course Carcinogenesis and Age-Attuned Care.Current oncology reports · 2026Review
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Authors and funding
8 authors.
Funding
Abstract
backgroundExposure to broad-spectrum antibiotics may alter the risk of early-onset colorectal cancer (eoCRC) via gut dysbiosis. We evaluated the associations between oral broad-spectrum and narrow-spectrum antibiotic use and eoCRC.
methodsWe conducted a nested case-control study within Kaiser Permanente Southern California (KPSC). Cases were persons aged 15 to 49 years with in situ or invasive colorectal adenocarcinoma (2009-2021); controls were individually matched 10:1 on age, sex, and length of KPSC membership. Those with ≥15 years of membership were included to assess exposure 2 to 15 years earlier. Data were collected from electronic health records. Crude and multivariable conditional logistic regression was used to evaluate antibiotic use from 10 to 14.9, 5 to 9.9, and 2 to 4.9 years before diagnosis/index date with the risk of overall colorectal cancer, colon cancer, and rectal cancer.
resultsA total of 295 cases and 2,794 controls were included. In the 10 to 14.9 years before diagnosis/index date, the use of broad-spectrum antibiotics was not associated with eoCRC [adjusted odds ratio (aOR) for any use = 1.07 (95% confidence interval, 0.82-1.40); aOR for >90 days of cumulative use = 1.40 (0.82-2.38)]. An elevated risk of colon adenocarcinoma was suggested for >90 days of cumulative use of broad-spectrum antibiotics [aOR = 2.04 (1.09-3.85)]. No clear association was observed for broad-spectrum antibiotic use within 5 to 9.9 or 2 to 4.9 years prior to diagnosis or with rectal cancer during any period or for narrow-spectrum antibiotics in any exposure window.
conclusionsAn association between long-term cumulative use of broad-spectrum antibiotics and early-onset colon cancer is suggested. IMPACT: Further investigation into antibiotics and eoCRC risk by the duration of use and the window of exposure is warranted.
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