Optimizing delivery of an anti-cytomegalovirus inhibitory peptide using a cell-penetrating peptide.

Komal Beeton, Jacob P Haskell, Dipanwita Mitra, Erin B Taylor, Gene L Bidwell

Abstract read

In one paragraph

Article in The Journal of general virology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Komal BeetonCenter for Immunology and Microbial Research, Department of Cell and Molecular Biology, University of Mississippi Medical Center, 2500 North State Street, Jackson, MS 39216, USA.

Jacob P HaskellDepartment of Neurology, University of Mississippi Medical Center, 2500 North State Street, Jackson, MS 39216, USA.

Dipanwita MitraCenter for Immunology and Microbial Research, Department of Cell and Molecular Biology, University of Mississippi Medical Center, 2500 North State Street, Jackson, MS 39216, USA.

Erin B TaylorCenter for Immunology and Microbial Research, Department of Cell and Molecular Biology, University of Mississippi Medical Center, 2500 North State Street, Jackson, MS 39216, USA.

Gene L BidwellCenter for Immunology and Microbial Research, Department of Cell and Molecular Biology, University of Mississippi Medical Center, 2500 North State Street, Jackson, MS 39216, USA.

Funding

The Impact of Obesity and Leptin on the Development of Immune System Dysfunction and Hypertension in Females with Systemic Lupus ErythematousU54HL169191 · NHLBI · AUGUSTA UNIVERSITY · PI Jennifer C Sullivan · 2023 to 2026

$7.4M

NHLBI NIH HHS U54 HL169191

6 · The paper itself

Abstract

Cytomegalovirus (CMV) is a beta herpesvirus that persists quiescently in healthy individuals but causes severe disease in immunocompromised patients and congenitally infected newborns. Side effects posed by the currently available antivirals necessitate the development of new antivirals with improved safety profiles. This study aims to optimize the potency of an anti-CMV peptide (P10) mimicking conserved region 2 of tegument pp150, fused with an elastin-like polypeptide (ELP). Our previous study has demonstrated that ELP-P10 inhibits murine cytomegalovirus (MCMV) growth

Indexed as

Antiviral AgentsCell-Penetrating PeptidesCytomegalovirusCytomegalovirus InfectionsAnimalsCell LineDisease Models, AnimalElastinElastin-Like PolypeptidesFemaleHumansMiceMice, Inbred BALB CMuromegalovirusAntiviral AgentsCell-Penetrating PeptidesElastinElastin-Like Polypeptidesantiviralscell-penetrating peptidecytomegaloviruselastin-like polypeptidepp150

Identifiers

PMID41528341

DOI10.1099/jgv.0.002210

PMCPMC12799271

What OpenQuestion holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.