Evidence map›Paper›PMID 41528127›Full record

ArticleeLife2026

Establishing synthetic ribbon-type active zones in a heterologous expression system.

Rohan Kapoor, Thanh Thao Do, Niko Schwenzer, Arsen Petrovic, Thomas Dresbach, Stephan E Lehnart, Rubén Fernández-Busnadiego, Tobias Moser

Abstract read
In one paragraph

Article in eLife, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Rohan KapoorInstitute for Auditory Neuroscience and InnerEarLab, University Medical Center Göttingen, Göttingen, Germany.ORCID https://orcid.org/0000-0002-4522-3289
Thanh Thao DoInstitute for Neuropathology, University Medical Centre Göttingen, Göttingen, Germany.ORCID https://orcid.org/0009-0004-2374-5803
Niko SchwenzerCluster of Excellence 'Multiscale Bioimaging: from Molecular Machines to Networks of Excitable Cells' (MBExC 2067), University of Göttingen, Göttingen, Germany.ORCID https://orcid.org/0000-0003-0794-5501
Arsen PetrovicCluster of Excellence 'Multiscale Bioimaging: from Molecular Machines to Networks of Excitable Cells' (MBExC 2067), University of Göttingen, Göttingen, Germany.ORCID https://orcid.org/0000-0003-4448-4230
Thomas DresbachInstitute of Anatomy and Embryology, University Medical Center Göttingen, Göttingen, Germany.ORCID https://orcid.org/0000-0002-2030-4787
Stephan E LehnartCluster of Excellence 'Multiscale Bioimaging: from Molecular Machines to Networks of Excitable Cells' (MBExC 2067), University of Göttingen, Göttingen, Germany.ORCID https://orcid.org/0000-0002-8115-3513
Rubén Fernández-BusnadiegoCluster of Excellence 'Multiscale Bioimaging: from Molecular Machines to Networks of Excitable Cells' (MBExC 2067), University of Göttingen, Göttingen, Germany.ORCID https://orcid.org/0000-0002-8366-7622
Tobias MoserInstitute for Auditory Neuroscience and InnerEarLab, University Medical Center Göttingen, Göttingen, Germany.ORCID https://orcid.org/0000-0001-7145-0533

Funding

Deutsche Forschungsgemeinschaft DFG Major Research Instrumentation program 448415290Deutsche Forschungsgemeinschaft EXC 2067/1 (MBExC)European Research Council 101054467Fondation Pour l'Audition FPA RD-2020-10Niedersächsisches Ministerium für Wissenschaft und Kultur Cryo-ET instrumentation fundingStudienstiftung des Deutschen Volkes PhD Fellowship
6 · The paper itself

Abstract

Encoding of several sensory modalities into neural signals is mediated by ribbon synapses. The synaptic ribbon tethers synaptic vesicles at the presynaptic active zone (AZ) and may act as a super-scaffold organizing AZ topography. Here, we employed a synthetic biology approach to reconstitute structures mimicking ribbon-type AZs in human embryonic kidney 293 (HEK293) cells for probing minimal molecular requirements and studying presynaptic Ca

Indexed as

Nerve Tissue ProteinsSynapsesAnimalsHair Cells, Auditory, InnerHEK293 CellsHumansSynthetic BiologyNerve Tissue Proteinsactive zonecalcium channelchannel clusterHEK cellshumanneuroscienceribbon synapsesynthetic biology

Identifiers

PMID41528127
PMCPMC12799213

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.