ArticleJournal of medicinal chemistry2026
A Series of Pyrazolo-Quinazoline Amines Inhibits the Cytochrome
Samsher Singh, Pearly Shuyi Ng, Umayal Lakshmanan, Vikneswaran Mathiyazakan, Thomas Wiggins, Bei Shi Lee, Shi Hua Ang, Sandra Wei Lin Sim, May Delos Santos, Garrett Moraski and 4 more
Abstract read
In one paragraphArticle in Journal of medicinal chemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
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0citing papers in PubMed
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What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
14 authors.
Samsher SinghNanyang Technological University, Lee Kong Chian School of Medicine, Singapore 636921, Singapore.
Pearly Shuyi NgExperimental Drug Development Centre, Agency for Science, Technology and Research, Singapore 138670, Singapore.ORCID 0000-0002-2276-7953 Umayal LakshmananExperimental Drug Development Centre, Agency for Science, Technology and Research, Singapore 138670, Singapore.
Vikneswaran MathiyazakanNanyang Technological University, Lee Kong Chian School of Medicine, Singapore 636921, Singapore.ORCID 0000-0002-2934-278X Thomas WigginsDepartment of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York 10461, United States.
Bei Shi LeeNanyang Technological University, Lee Kong Chian School of Medicine, Singapore 636921, Singapore.
Shi Hua AngExperimental Drug Development Centre, Agency for Science, Technology and Research, Singapore 138670, Singapore.
Sandra Wei Lin SimExperimental Drug Development Centre, Agency for Science, Technology and Research, Singapore 138670, Singapore.
May Delos SantosAntimicrobial Resistance Interdisciplinary Research Group, Singapore-MIT Alliance for Research and Technology Centre, Singapore 138602, Singapore.
Garrett MoraskiDepartment of Chemistry and Biochemistry, Montana State University, 103 Chemistry and Biochemistry, Bozeman, Montana 59717, United States.ORCID 0000-0002-6992-5584 Marvin MillerDepartment of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, Indiana 46556, United States.ORCID 0000-0002-3704-8214 Michael BerneyDepartment of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York 10461, United States.
Gerhard GrüberSchool of Biological Sciences, Nanyang Technological University, Singapore 637551, Singapore.ORCID 0000-0002-5730-8319 Kevin PetheNanyang Technological University, Lee Kong Chian School of Medicine, Singapore 636921, Singapore.ORCID 0000-0003-0916-8873 Funding
Design, Syntheses and Studies of Novel Antituberculosis AgentsR37AI054193 · NIAID · UNIVERSITY OF NOTRE DAME · PI MILLER, MARVIN J · 2016 to 2025
$5.2MNIAID NIH HHS R37 AI054193
6 · The paper itselfAbstract
Indexed as
AminesAntitubercular AgentsEnzyme InhibitorsMycobacterium tuberculosisOxidoreductasesPyrazolesQuinazolinesAnimalsHumansMicrobial Sensitivity TestsStructure-Activity RelationshipAminesAntitubercular AgentsEnzyme InhibitorsOxidoreductasesPyrazolesQuinazolines
Identifiers
PMID41528067
PMCPMC12910597
What OpenQuestion holds
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LicenceCC BY-NC-ND
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