Evidence map›Paper›PMID 41527874›Full record

ArticleEmerging microbes & infections2026

Astrovirus and norovirus infections and their association with diarrheal symptoms in immunocompromised children.

Amy E Davis, Yin Su, Ronald Dallas, Pamela Freiden, Janet A Englund, Eileen J Klein, Hana Hakim, Randall Hayden, Gabriela Maron, Elisa Margolis and 3 more

Abstract read
In one paragraph

Article in Emerging microbes & infections, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Amy E DavisDepartment of Host-Microbe Interactions, St. Jude Children's Research Hospital, Memphis, TN, USA.
Yin SuDepartment of Biostatistics, St. Jude Children's Research Hospital, Memphis, TN, USA.
Ronald DallasDepartment of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, TN, USA.
Pamela FreidenDepartment of Host-Microbe Interactions, St. Jude Children's Research Hospital, Memphis, TN, USA.
Janet A EnglundDepartment of Pediatrics, University of Washington, Seattle Children's Research Institute, Seattle, WA, USA.ORCID 0000-0003-1134-4178
Eileen J KleinDepartment of Pediatrics, University of Washington, Seattle Children's Research Institute, Seattle, WA, USA.
Hana HakimDepartment of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, TN, USA.
Randall HaydenDepartment of Pathology, St. Jude Children's Research Hospital, Memphis, TN, USA.
Gabriela MaronDepartment of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, TN, USA.
Elisa MargolisDepartment of Host-Microbe Interactions, St. Jude Children's Research Hospital, Memphis, TN, USA.
Li TangDepartment of Biostatistics, St. Jude Children's Research Hospital, Memphis, TN, USA.
Valerie CortezDepartment of Molecular, Cell & Developmental Biology, University of California, Santa Cruz, Santa Cruz, CA, USA.
Stacey Schultz-CherryDepartment of Host-Microbe Interactions, St. Jude Children's Research Hospital, Memphis, TN, USA.ORCID 0000-0002-2021-727X

Funding

Training in the Design and Development of Infectious Disease TherapeuticsT32AI106700 · NIAID · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI Richard E. Lee · 2015 to 2026
$2.1M
Do they or don't they: astrovirus-induced diarrheaR21AI135254 · NIAID · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI SCHULTZ-CHERRY, STACEY L · 2018 to 2019
$561k
Astrovirus modulation of gut immunity via goblet cellsK22AI156116 · NIAID · UNIVERSITY OF CALIFORNIA SANTA CRUZ · PI CORTEZ, VALERIE · 2021 to 2022
$312k
NIAID NIH HHS K22 AI156116NIAID NIH HHS R21 AI135254NIAID NIH HHS T32 AI106700
6 · The paper itself

Abstract

Human astroviruses are a common cause of viral gastroenteritis and are often underdiagnosed. While infections are typically mild or asymptomatic in immunocompetent hosts, astrovirus can cause prolonged and severe disease in immunocompromised individuals. Here, we conducted a case-control study to evaluate the clinical presentation of astrovirus infections in paediatric oncology patients. Our findings were compared to two groups: (1) norovirus infections in the same immunocompromised cohort, and (2) a cohort of immunocompetent children with and without diarrheal symptoms. Astrovirus was detected in 9.8% of immunocompromised patients, with prolonged shedding seen in multiple cases. Astrovirus infection was associated with an increased odds of diarrhoea, although this association weakened when adjusting for co-infections. In contrast, norovirus was not significantly associated with diarrhoea in immunocompromised patients, despite prolonged shedding in 24% of the cohort. High rates of co-infection with adenovirus and

Indexed as

Astroviridae InfectionsCaliciviridae InfectionsDiarrheaGastroenteritisImmunocompromised HostMamastrovirusNorovirusCase-Control StudiesChildChild, PreschoolCoinfectionFecesFemaleHumansInfantMalediarrhoeaenteric viral infectionsgastroenteritisHuman astrovirusimmunocompromised childrennorovirusviral co-infection

Identifiers

PMID41527874
PMCPMC12857711

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.