Evidence map›Paper›PMID 41527828›Full record

Observational studyInfection control and hospital epidemiology2026

Clinical utility of serial plasma cell-free DNA metagenomic next-generation sequencing assays.

Ishminder Kaur, Bennett Shaw, Ashrit Multani, Sanchi Malhotra, Huan Vinh Dong, Christy Lukose, Kavitha Prabaker, Tawny Saleh, Young Bo Sim, Christopher N Tymchuk and 4 more

Abstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Infection control and hospital epidemiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Ishminder KaurDivision of Infectious Diseases, Department of Pediatrics, David Geffen School of Medicine, https://ror.org/046rm7j60University of California, Los Angeles, CA, USA.ORCID https://orcid.org/0000-0002-1759-8788
Bennett ShawDepartment of Medicine, University of California, Los Angeles, CA, USA.
Ashrit MultaniDivision of Infectious Diseases, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA, USA.ORCID https://orcid.org/0000-0003-4043-4287
Sanchi MalhotraDivision of Infectious Diseases, Department of Pediatrics, David Geffen School of Medicine, https://ror.org/046rm7j60University of California, Los Angeles, CA, USA.ORCID https://orcid.org/0000-0002-2485-3927
Huan Vinh DongDivision of Infectious Diseases, Department of Pediatrics, David Geffen School of Medicine, https://ror.org/046rm7j60University of California, Los Angeles, CA, USA.ORCID https://orcid.org/0000-0002-6370-1811
Christy LukoseDepartment of Pediatrics, David Geffen School of Medicine, University of California, Los Angeles, CA, USA.
Kavitha PrabakerDivision of Infectious Diseases, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA, USA.
Tawny SalehDivision of Infectious Diseases, Department of Pediatrics, David Geffen School of Medicine, https://ror.org/046rm7j60University of California, Los Angeles, CA, USA.
Young Bo SimDepartment of Pediatrics, David Geffen School of Medicine, University of California, Los Angeles, CA, USA.ORCID https://orcid.org/0000-0002-7510-1522
Christopher N TymchukDivision of Infectious Diseases, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA, USA.
Daniel Z UslanDivision of Infectious Diseases, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA, USA.ORCID https://orcid.org/0000-0002-9800-3482
Helen ZhouDepartment of Pediatrics, David Geffen School of Medicine, University of California, Los Angeles, CA, USA.ORCID https://orcid.org/0009-0009-0329-2989
Timothy F BrewerDivision of Infectious Diseases, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA, USA.ORCID https://orcid.org/0000-0002-5615-1639
Shangxin YangDepartment of Pathology and Laboratory Medicine, University of California, Los Angeles, CA, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This single center retrospective observational study of serial plasma metagenomic next-generation sequencing testing shows that >95% of serial testing was without meaningful clinical impact. Only 5/173 cases were adjudicated as having significant clinical impact.

Indexed as

Cell-Free Nucleic AcidsHigh-Throughput Nucleotide SequencingMetagenomicsFemaleHumansMaleRetrospective StudiesCell-Free Nucleic Acidsclinical utilitydiagnostic stewardshipKarius testmetagenomic next-generation sequencingPlasma cell-free DNAserial testing

Identifiers

PMID41527828
PMCPMC12932917

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.