Evidence map›Paper›PMID 41527820›Full record

ArticleCirculation research2026

Control of Blood Pressure Variability Across Behavioral States by Brainstem Adrenergic Neurons.

George M P R Souza, Harsha Thakkalapally, Faye E Berry, Leah F Wisniewski, Ulrich M Atongazi, Daniel S Stornetta, Stephen B G Abbott

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Circulation research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

George M P R SouzaDepartment of Pharmacology, University of Virginia, Charlottesville (G.M.P.R.S., H.T., F.E.B., L.F.W., U.M.A., D.S.S., S.B.G.A.).ORCID 0000-0003-4678-6910
Harsha ThakkalapallyDepartment of Pharmacology, University of Virginia, Charlottesville (G.M.P.R.S., H.T., F.E.B., L.F.W., U.M.A., D.S.S., S.B.G.A.).ORCID 0009-0008-3796-3819
Faye E BerryDepartment of Pharmacology, University of Virginia, Charlottesville (G.M.P.R.S., H.T., F.E.B., L.F.W., U.M.A., D.S.S., S.B.G.A.).
Leah F WisniewskiDepartment of Pharmacology, University of Virginia, Charlottesville (G.M.P.R.S., H.T., F.E.B., L.F.W., U.M.A., D.S.S., S.B.G.A.).
Ulrich M AtongaziDepartment of Pharmacology, University of Virginia, Charlottesville (G.M.P.R.S., H.T., F.E.B., L.F.W., U.M.A., D.S.S., S.B.G.A.).
Daniel S StornettaDepartment of Pharmacology, University of Virginia, Charlottesville (G.M.P.R.S., H.T., F.E.B., L.F.W., U.M.A., D.S.S., S.B.G.A.).
Stephen B G AbbottDepartment of Pharmacology, University of Virginia, Charlottesville (G.M.P.R.S., H.T., F.E.B., L.F.W., U.M.A., D.S.S., S.B.G.A.).ORCID 0000-0003-1244-3637

Funding

Role of presympathetic neurons of the hindbrain in cardiovascular controlR01HL148004 · NHLBI · UNIVERSITY OF VIRGINIA · PI ABBOTT, STEPHEN · 2019 to 2023
$2.6M
NHLBI NIH HHS R01 HL148004
6 · The paper itself

Abstract

backgroundShort-term blood pressure (BP) variability is increasingly recognized as an independent predictor of cardiovascular and cerebrovascular risks, yet the central neural mechanisms that govern this variability, particularly across behavioral states, remain poorly defined.

methodsWe investigated the role of rostral ventrolateral medulla C1 (RVLM

resultsRVLM

conclusionsRVLM

Indexed as

Adrenergic NeuronsBehavior, AnimalBlood PressureBrain StemMedulla OblongataAnimalsBaroreflexMaleRatsRats, Sprague-DawleySleepWakefulnessarousalbaroreflexblood pressurebraincritical illnesssleepstress, psychological

Identifiers

PMID41527820
PMCPMC12994584

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.