Evidence map›Paper›PMID 41527812›Full record

ArticleHistology and histopathology2026

AHNAK2 is a novel diagnostic biomarker for gallbladder adenocarcinoma.

Lingli Chen, Qi Song, Lei Xu, Xinyi Zhang, Minying Deng, Jie Huang, Jieakesu Su, Huimei Wang, Yingyong Hou

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Article in Histology and histopathology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

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9 authors.

Lingli Chen *Department of Pathology, Zhongshan Hospital, Fudan University, Shanghai, China.
Qi Song *Department of Pathology, Zhongshan Hospital, Fudan University, Shanghai, China.
Lei Xu *Department of Pathology, Zhongshan Hospital, Fudan University, Shanghai, China.
Xinyi ZhangDepartment of Pathology, Zhongshan Hospital, Fudan University, Shanghai, China.
Minying DengDepartment of Pathology, Zhongshan Hospital, Fudan University, Shanghai, China.
Jie HuangDepartment of Pathology, Zhongshan Hospital, Fudan University, Shanghai, China.
Jieakesu SuDepartment of Pathology, Zhongshan Hospital, Fudan University, Shanghai, China.
Huimei WangDepartment of Pathology, Zhongshan Hospital, Fudan University, Shanghai, China.
Yingyong HouDepartment of Pathology, Zhongshan Hospital, Fudan University, Shanghai, China. Hou.yingyong@zs-hospital.sh.cn.

Funding

National Natural Science Foundation of China 32400754Shanghai Municipal Health Commission 2024ZZ1023Shanghai Municipal Health Commission General Project 202240004Shanghai Sailing Program No.23YF1446800Youth Foundation of Zhongshan Hospital, Fudan University No.2022ZSQN03
6 · The paper itself

Abstract

objectiveTo investigate the pathological diagnostic value of AHNAK2 in gallbladder carcinoma (GBC), especially in adenocarcinoma (AC).

methodsTissue microarrays (TMAs) were constructed from 296 gallbladder tumor cases, comprising 562 cores that included normal/atypical epithelium, low-grade intraepithelial neoplasia (LGIN), high-grade intraepithelial neoplasia/carcinoma in situ (HGIN/TIS), and GBC. Immunohistochemical staining for AHNAK2 and IMP3 was performed on these TMAs and another 10 GBC cases, and the sensitivity and specificity of AHNAK2 were assessed across different gallbladder tumor types.

resultsAHNAK2 immunohistochemical expression demonstrated a progressive increase across pathological stages (

conclusionAHNAK2 demonstrates moderate sensitivity and high specificity in the pathological diagnosis of GBC, particularly for well-differentiated ACs. Combining AHNAK2 with IMP3 significantly enhances diagnostic sensitivity, achieving up to 90% across all AC grades.

Indexed as

AdenocarcinomaBiomarkers, TumorGallbladder NeoplasmsNeoplasm ProteinsAdultAgedCytoskeletal ProteinsFemaleHumansImmunohistochemistryMaleMiddle AgedSensitivity and SpecificityTissue Array AnalysisAHNAK2 protein, humanBiomarkers, TumorCytoskeletal ProteinsNeoplasm Proteins

Identifiers

PMID41527812

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