Evidence map›Paper›PMID 41527791›Full record

ArticleEmerging microbes & infections2026

HIV expression persists in the cerebrospinal fluid of HIV-associated neurocognitive disorders despite effective ART.

Gabriela S Prates, Xiaoyi Li, Victor Folgosi, Ciniso S Shabangu, George G Souza, Carlos Apoliano, Maria R Gascon, Mariana A Monteiro, Carolina Gualqui, Rosangela Santos Eichler and 6 more

Abstract read
In one paragraph

Article in Emerging microbes & infections, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Gabriela S PratesLaboratory of Medical Investigation LIM-56, Division of Dermatology, Faculty of Medicine, University of São Paulo, São Paulo, Brazil.
Xiaoyi LiUNC HIV Cure Center & Department of Biochemistry and Biophysics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Victor FolgosiLaboratory of Medical Investigation LIM-56, Division of Dermatology, Faculty of Medicine, University of São Paulo, São Paulo, Brazil.
Ciniso S ShabanguUNC HIV Cure Center & Department of Biochemistry and Biophysics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
George G SouzaLaboratory of Medical Investigation LIM-56, Division of Dermatology, Faculty of Medicine, University of São Paulo, São Paulo, Brazil.
Carlos ApolianoLaboratory of Medical Investigation LIM-56, Division of Dermatology, Faculty of Medicine, University of São Paulo, São Paulo, Brazil.
Maria R GasconLaboratory of Medical Investigation LIM-56, Division of Dermatology, Faculty of Medicine, University of São Paulo, São Paulo, Brazil.
Mariana A MonteiroSecondary Immunodeficiency Clinic, Department of Dermatology, Hospital das Clínicas, University of São Paulo, São Paulo, Brazil.
Carolina GualquiSecondary Immunodeficiency Clinic, Department of Dermatology, Hospital das Clínicas, University of São Paulo, São Paulo, Brazil.
Rosangela Santos EichlerDepartment of Pharmacology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil.
Helio GomesLaboratory of Investigation in Neurology - LIM15, Faculty of Medicine, University of São Paulo, São Paulo, Brazil.
Nikesh KatuwalUNC HIV Cure Center & Department of Biochemistry and Biophysics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Cassandra GilbertUniversity of North Carolina at Chapel Hill Center for AIDS Research (CFAR), Chapel Hill, NC, USA.
Yuyang TangUNC HIV Cure Center & Department of Biochemistry and Biophysics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Jorge CassebLaboratory of Medical Investigation LIM-56, Division of Dermatology, Faculty of Medicine, University of São Paulo, São Paulo, Brazil.
Guochun JiangUNC HIV Cure Center & Department of Biochemistry and Biophysics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.

Funding

Structural Biology CoreU54AI170855 · NIAID · SEATTLE CHILDREN'S HOSPITAL · PI Bruce Edward Torbett · 2022 to 2026
$36.7M
Collaboratory of AIDS Researchers for Eradication (CARE)UM1AI164567 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI DAVID M. MARGOLIS · 2021 to 2026
$31.6M
Defining the HIV reservoir and latency mechanism in human brain myeloid cellsR01MH136852 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Guochun Jiang · 2024 to 2026
$2.3M
Histone decrotonylation uniquely regulates HIV latencyR01AI186609 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Guochun Jiang · 2024 to 2026
$2.2M
Characterize replication competent myeloid reservoirs in the central nervous systemR21MH128034 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI JIANG, GUOCHUN · 2021 to 2022
$443k
Novel Epigenetic Marks for HIV Latency Entry and ReversalR21AI167709 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI JIANG, GUOCHUN · 2023 to 2024
$428k
NIAID NIH HHS R01 AI186609NIAID NIH HHS R21 AI167709NIAID NIH HHS U54 AI170855NIAID NIH HHS UM1 AI164567NIMH NIH HHS R01 MH136852NIMH NIH HHS R21 MH128034
6 · The paper itself

Abstract

Despite effective antiretroviral therapy (ART), HIV-associated neurocognitive disorders (HAND) persist in people with HIV (PWH). The central nervous system (CNS) may act as a viral reservoir due to limited ART penetration and virological discordance between plasma and cerebrospinal fluid (CSF). In a cross-sectional study of 24 ART-treated PWH, participants were stratified as cognitively normal (CN,

Indexed as

AIDS Dementia ComplexAnti-HIV AgentsHIV-1HIV InfectionsNeurocognitive DisordersAdultCross-Sectional StudiesFemaleHumansMaleMiddle AgedRNA, ViralTenofovirViral LoadAnti-HIV AgentsRNA, ViralTenofovircerebrospinal fluidHIV-associated neurocognitive disordersHIV latencyHIV persistenceHIV reservoirpeptidomics

Identifiers

PMID41527791
PMCPMC12872101

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.