ArticleCureus2025
Persistent Refractory Headaches Following Non-alcoholic Wernicke's Encephalopathy in a Teenager.
Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
2 authors.
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Abstract
Wernicke's encephalopathy (WE) is a neurological condition that presents with a clinical triad of ophthalmoparesis with nystagmus, confabulation, and ataxia. It is caused by thiamine deficiency (Vitamin B1), commonly associated with chronic alcoholism as well as non-alcoholic causes, and early diagnosis with prompt thiamine replacement is essential to prevent irreversible neurological damage. We report the case of a 17-year-old girl who lost 18 kg in one month due to aggressive dietary control without appropriate nutritional support and developed neurological signs that were consistent with WE. A clinical diagnosis of WE was made, and the patient was treated with intravenous and oral thiamine. She showed significant improvement in neurological symptoms, but also developed a new, persistent, refractory headache, which remained unresolved despite extensive pharmacologic and interventional headache treatments. Persistent headaches in the post-WE setting, as seen in this case, may represent a novel or underreported sequela that requires further research and clinical awareness.
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