ArticleHealth science reports2026
Automated Thromboelastometry for Semiquantitative Assessment of High Heparin Concentrations: A Feasibility Study in Healthy Volunteers.
Article in Health science reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
1 citing paper in PubMed.
- Automated Thromboelastometry for Semiquantitative Assessment of High Heparin Concentrations: A Feasibility Study in Healthy Volunteers.Health science reports · 2026Article
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background and Aims: To date, thromboelastometry has not been investigated as an assay to monitor profound heparin anticoagulation, such as is required for a safe cardiopulmonary bypass (CPB). The aim of this study was to test the feasibility of automated thromboelastometry for semiquantitative assessment of increasing heparin concentrations. Methods: Blood samples were collected from 20 healthy adult volunteers that were recruited to participate in the study. The citrated blood tubes were spiked with unfractionated heparin to concentrations of 0, 1, 2, 3, 4, 5 and 6 IU/mL. From each concentration, point-of-care viscoelastic testing was performed using the HEPTEM, INTEM, EXTEM, and FIBTEM cartridges of the fully automated ROTEM Sigma device. Linear mixed model with regression analysis and receiver operating characteristics (ROC) curves were used to analyze the data. Results: HEPTEM coagulation time (CT) was linearly prolonged by 5 s (95% CI, 4-6 s, Conclusion: This study on automated thromboelastometry demonstrated a dose-dependent prolongation of HEPTEM CT when heparin concentration increased from 0 to 6 IU/mL. Furthermore, ROC analysis on the ability of HEPTEM CT to detect heparin concentrations of ≥ 4 IU/mL indicated possible diagnostic potential. These novel findings suggest that HEPTEM CT is a feasible ROTEM Sigma parameter for semiquantitative assessment of heparin concentrations required for safe CPB. However, this remains to be verified in future clinical studies.
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Registered trials
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