Evidence map›Paper›PMID 41527525›Full record

ArticleJournal of cosmetic dermatology2026

Targeting Circadian Rhythm for the Regulation of Skin Collagen Metabolism.

Cheng Wang, Tianlin Song, Yurong Zhang, Nihong Li, Ling Xie, Min Xie, Xingwu Jiang, Guanglei Lü, Yun Meng, Chaochao Wang and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of cosmetic dermatology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Cheng WangShanghai East Hospital, School of Medicine, Tongji University, Shanghai, P. R. China.ORCID https://orcid.org/0009-0009-8641-4696
Tianlin SongShanghai East Hospital, School of Medicine, Tongji University, Shanghai, P. R. China.
Yurong ZhangShanghai East Hospital, School of Medicine, Tongji University, Shanghai, P. R. China.
Nihong LiScientific Research Laboratory, Shanghai Le-Surely Biotechnology Co. Ltd, Shanghai, P. R. China.
Ling XieScientific Research Laboratory, Shanghai Le-Surely Biotechnology Co. Ltd, Shanghai, P. R. China.
Min XieScientific Research Laboratory, Shanghai Le-Surely Biotechnology Co. Ltd, Shanghai, P. R. China.
Xingwu JiangZhejiang Key Laboratory of Extreme Environment Functional Materials, Yiwu Research Institute of Fudan University, Yiwu, China.ORCID https://orcid.org/0000-0003-1516-0608
Guanglei LüZhejiang Key Laboratory of Extreme Environment Functional Materials, Yiwu Research Institute of Fudan University, Yiwu, China.
Yun MengShanghai East Hospital, School of Medicine, Tongji University, Shanghai, P. R. China.
Chaochao WangShanghai East Hospital, School of Medicine, Tongji University, Shanghai, P. R. China.
Lijun YueShanghai East Hospital, School of Medicine, Tongji University, Shanghai, P. R. China.
Wei YangShanghai East Hospital, School of Medicine, Tongji University, Shanghai, P. R. China.
Yang LiZhejiang Key Laboratory of Extreme Environment Functional Materials, Yiwu Research Institute of Fudan University, Yiwu, China.
Yelin WuShanghai East Hospital, School of Medicine, Tongji University, Shanghai, P. R. China.
Liang ChenScientific Research Laboratory, Shanghai Le-Surely Biotechnology Co. Ltd, Shanghai, P. R. China.ORCID https://orcid.org/0009-0006-7795-1375

Funding

National Natural Science Foundation of China 82172091National Natural Science Foundation of China 82372122National Natural Science Foundation of China 82402450National Natural Science Foundation of China U25A20245Shanghai Science and Technology Innovation Action Plan 23S31900200Shanghai Science and Technology Innovation Action Plan 23XD1422800The Medical Discipline Construction Program of Shanghai Pudong New Area Health Commission PWXx2025-03
6 · The paper itself

Abstract

backgroundCollagen is essential for maintaining skin structure and function, and the circadian rhythm is known to regulate a wide range of physiological processes.

aimsTo investigate whether collagen metabolism in human skin fibroblasts exhibits circadian regulation, and to evaluate whether the time-coordinated application of baicalin at daytime and palmitoyl tripeptide-1 (PT-1) at nighttime synergistically promotes collagen fiber formation and improves overall skin quality.

methodsA circadian-synchronized human skin fibroblast model was established. The expression of collagen metabolism-related genes was analyzed using qPCR and immunofluorescence. Subsequently, an 8-week topical application study was conducted in mice using a regimen of daytime baicalin and nighttime PT-1. Finally, a clinical trial involving 30 female participants was conducted, employing the same time-coordinated application scheme.

resultsFibroblasts exhibited opposing day-night rhythms: genes for collagen assembly (e.g., LOX) peaked during the day, while those involved in synthesis/secretion (e.g., Sec61a2, Mia3, Pde4d, Vps33b) and degradation (e.g., CTSK, MMP1) peaked at night. Time phase-dependent interventions showed baicalin enhanced daytime assembly, while PT-1 boosted nighttime synthesis. In mice, a timed day-night combination therapy increased collagen fiber density. Clinical trial (n = 30) confirmed the efficacy, showing significant improvements in skin luminance (+16.29%), nasolabial fold depth (-36.35%), and firmness (R2: +24.35%).

conclusionsCollagen metabolism is regulated by circadian rhythms. Chronomodulated baicalin and PT-1 application synergistically optimize collagen metabolism and improve skin quality.

Indexed as

Circadian RhythmCollagenFlavonoidsOligopeptidesSkinAdultAnimalsCells, CulturedFemaleFibroblastsHumansMiceMiddle AgedSkin AgingbaicalinCollagenFlavonoidsOligopeptidesbaicalincircadian rhythmcollagen metabolismpalmitoyl tripeptide‐1skin aging

Identifiers

PMID41527525
PMCPMC12797011

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.