Evidence map›Paper›PMID 41527523›Full record

ArticleJournal of cellular and molecular medicine2026

STAT3 SH2 Domain Aspartic Acid 661 Mutations Activate Immune Gene Programs.

Hye Kyung Lee, Gyuhyeok Cho, Jichun Chen, Aaron B Schultz, Sung-Gwon Lee, Chengyu Liu, Priscilla A Furth, Neal S Young, Jungwook Kim, Alejandro Villarino and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of cellular and molecular medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. STAT3 SH2 Domain Aspartic Acid 661 Mutations Activate Immune Gene Programs.Journal of cellular and molecular medicine · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Hye Kyung LeeSection of Genetics and Physiology, National Institute of Diabetes and Digestive and Kidney Diseases, US National Institutes of Health, Bethesda, Maryland, USA.ORCID https://orcid.org/0000-0002-7785-5942
Gyuhyeok ChoDepartment of Chemistry, Gwangju Institute of Science and Technology (GIST), Gwangju, Korea.ORCID https://orcid.org/0000-0001-6785-616X
Jichun ChenHematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland, USA.
Aaron B SchultzDepartment of Microbiology and Immunology, Miller School of Medicine, University of Miami, Miami, Florida, USA.
Sung-Gwon LeeSection of Genetics and Physiology, National Institute of Diabetes and Digestive and Kidney Diseases, US National Institutes of Health, Bethesda, Maryland, USA.ORCID https://orcid.org/0000-0002-0928-9950
Chengyu LiuTransgenic Core, National Heart, Lung, and Blood Institute, US National Institutes of Health, Bethesda, Maryland, USA.ORCID https://orcid.org/0000-0002-5136-9225
Priscilla A FurthSection of Genetics and Physiology, National Institute of Diabetes and Digestive and Kidney Diseases, US National Institutes of Health, Bethesda, Maryland, USA.ORCID https://orcid.org/0000-0003-3883-0715
Neal S YoungHematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland, USA.ORCID https://orcid.org/0009-0007-0999-2519
Jungwook KimDepartment of Chemistry, Gwangju Institute of Science and Technology (GIST), Gwangju, Korea.ORCID https://orcid.org/0000-0001-5213-9299
Alejandro VillarinoDepartment of Microbiology and Immunology, Miller School of Medicine, University of Miami, Miami, Florida, USA.ORCID https://orcid.org/0000-0001-8068-2176
Lothar HennighausenSection of Genetics and Physiology, National Institute of Diabetes and Digestive and Kidney Diseases, US National Institutes of Health, Bethesda, Maryland, USA.ORCID https://orcid.org/0000-0001-8319-9841

Funding

Tumor Biology Research ProgramP30CA240139 · NCI · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI Stephen D. Nimer · 2019 to 2026
$24.1M
Predoctoral Training in Translational ImmunologyT32AI162624 · NIAID · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI Thomas R Malek · 2022 to 2026
$894k
Leukemia Research Foundation AWD-009890National Heart, Lung and Blood InstituteNational Institute of Allergy and Infectious Diseases T32AI162624National Research Foundation of Korea RS-2024-00411137National Research Foundation of Korea RS-2024-00440614NCI NIH HHS P30 CA240139NIAID NIH HHS T32 AI162624NIDDK NIH HHSNIH HHSSylvester Comprehensive Cancer Center, University of Miami Health Systems PG012707Sylvester Comprehensive Cancer Center, University of Miami Health Systems PG013596U.S. Department of Health and Human Services
6 · The paper itself

Abstract

The conserved aspartic acid residue D661 within the STAT3 SH2 domain is a recurrent mutational hotspot in hematologic malignancies, including T-cell large granular lymphocytic leukaemia, myelodysplastic syndromes and acute lymphoblastic leukaemia. To define the functional consequences of distinct STAT3

Indexed as

Aspartic AcidMutationsrc Homology DomainsSTAT3 Transcription FactorAnimalsHumansMiceAspartic AcidSTAT3 protein, humanSTAT3 Transcription FactorD661 variantsgain‐of‐functionhematologic malignanciesimmune dysregulationSTAT3

Identifiers

PMID41527523
PMCPMC12796846

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.