Evidence map›Paper›PMID 41527434›Full record

ArticleeLife2026

Hypothalamic deiodinase type-3 establishes the period of circannual interval timing in mammals.

Calum Stewart, T Adam Liddle, Elisabetta Tolla, Jo Edward Lewis, Christopher Marshall, Neil P Evans, Peter J Morgan, Fran J P Ebling, Tyler J Stevenson

Abstract read
In one paragraph

Article in eLife, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Prolactin and Triiodothyronine Modulate Seasonal Variation in Brown Adipose Tissue in Djungarian Hamsters.Journal of experimental zoology. Part A, Ecological and integrative physiology · 2026
    Article
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Calum StewartSchool of Biodiversity, One Health, and Veterinary Medicine, University of Glasgow, Glasgow, United Kingdom.ORCID https://orcid.org/0000-0002-6216-6044
T Adam LiddleSchool of Biodiversity, One Health, and Veterinary Medicine, University of Glasgow, Glasgow, United Kingdom.
Elisabetta TollaSchool of Biodiversity, One Health, and Veterinary Medicine, University of Glasgow, Glasgow, United Kingdom.ORCID https://orcid.org/0009-0002-3425-233X
Jo Edward LewisInstitute of Metabolic Science-Metabolic Research Laboratories & MRC-Metabolic Diseases Unit, University of Cambridge, Cambridge, United Kingdom.ORCID https://orcid.org/0000-0002-5722-6778
Christopher MarshallSchool of Physiology, Pharmacology and Neuroscience, University of Bristol, Bristol, United Kingdom.ORCID https://orcid.org/0000-0002-5658-9817
Neil P EvansSchool of Biodiversity, One Health, and Veterinary Medicine, University of Glasgow, Glasgow, United Kingdom.
Peter J MorganRowett Institute, University of Aberdeen, Aberdeen, United Kingdom.ORCID https://orcid.org/0000-0002-5071-6512
Fran J P EblingSchool of Life Sciences, University of Nottingham, Nottingham, United Kingdom.
Tyler J StevensonSchool of Biodiversity, One Health, and Veterinary Medicine, University of Glasgow, Glasgow, United Kingdom.ORCID https://orcid.org/0000-0003-2644-9685

Funding

Leverhulme Trust LT-RL-2019-06Wellcome TrustWellcome Trust Institutional Strategic Support Fund
6 · The paper itself

Abstract

Animals respond to environmental cues to time phenological events, but the intrinsic mechanism of circannual timing remains elusive. We used transcriptomic sequencing and frequent sampling of multiple hypothalamic nuclei in Djungarian hamsters to examine the neural and molecular architecture of circannual interval timing. Our study identified three distinct phases of transcript changes, with deiodinase type-3 (

Indexed as

HypothalamusIodide PeroxidasePhodopusAnimalsCricetinaeMalePhotoperiodSeasonsIodide Peroxidaseiodothyronine deiodinase type IIIhamsterhypothalamusneurosciencephotoperiodismseasonality

Identifiers

PMID41527434
PMCPMC12799211

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.