ReviewExpert reviews in molecular medicine2026
Main events and mechanism of human erythrocyte ageing.
Review in Expert reviews in molecular medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
3 citing papers in PubMed.
- Tissue-Resident Macrophages: Linking Physiology and Inflammation in Infection.Clinical reviews in allergy & immunology · 2026Review
- Repurposing Tyrosine Kinase Inhibitors for Sickle Cell Disease: Focus on Band 3 Phosphorylation.Biomedicines · 2026Review
- Recover aged/damaged erythrocytes and prevent them from aging by remodeling or enhancing their vital proteins: Hb and B3p.Frontiers in cell and developmental biology · 2026Article
Corrections and comments
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Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Erythrocytes play a crucial role in human life and are a good model for single-cell ageing research. Therefore, the mechanism of erythrocyte ageing has been a serious concern for researchers. Here, we investigate the ageing mechanism of human erythrocytes in circulation with a new approach. We first try to discover all the factors that affect erythrocyte ageing from the existing findings about the interactions of erythrocytes with the environment during circulation and the resulting alterations in the cells during their ageing process. Then, we define the main events in erythrocyte ageing according to the incidence and strength of the interactions and the magnitude of the biophysical and biochemical alterations induced by these interactions. With the main events as a guide for tracking the ageing process and analysing the causes and consequences of the events taking place during erythrocyte ageing, we depict the pathways and framework of the ageing mechanism. We hope that understanding the ageing mechanism of erythrocytes will help people to have a deep insight into the biophysical and biochemical processes of cell ageing and their molecular basis. Additionally, it may offer solutions to different fundamental and practical problems related to erythrocyte ageing, storage lesions, transfusion and diseases.
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Registered trials
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