Evidence map›Paper›PMID 41527298›Full record

ArticleJournal of integrative plant biology2026

Heterogeneity of iridoid biosynthesis in catmints: Molecular background in a phylogenetic context.

Tijana Banjanac, Milica Milutinović, Dragana Matekalo, Neda Popović, Luka Petrović, Uroš Gašić, Marijana Skorić, Branislav Šiler, Tamara Lukić, Ana Stupar and 6 more

Abstract read
In one paragraph

Article in Journal of integrative plant biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Tijana BanjanacDepartment of Plant Physiology, Institute for Biological Research "Siniša Stanković"-National Institute of the Republic of Serbia, University of Belgrade, Belgrade, 11108, Serbia.ORCID https://orcid.org/0000-0001-9023-9135
Milica MilutinovićDepartment of Plant Physiology, Institute for Biological Research "Siniša Stanković"-National Institute of the Republic of Serbia, University of Belgrade, Belgrade, 11108, Serbia.ORCID https://orcid.org/0000-0003-0619-0709
Dragana MatekaloDepartment of Plant Physiology, Institute for Biological Research "Siniša Stanković"-National Institute of the Republic of Serbia, University of Belgrade, Belgrade, 11108, Serbia.ORCID https://orcid.org/0000-0001-6565-4580
Neda PopovićDepartment of Plant Physiology, Institute for Biological Research "Siniša Stanković"-National Institute of the Republic of Serbia, University of Belgrade, Belgrade, 11108, Serbia.ORCID https://orcid.org/0000-0003-4184-1263
Luka PetrovićDepartment of Plant Physiology, Institute for Biological Research "Siniša Stanković"-National Institute of the Republic of Serbia, University of Belgrade, Belgrade, 11108, Serbia.ORCID https://orcid.org/0000-0002-3672-7979
Uroš GašićDepartment of Plant Physiology, Institute for Biological Research "Siniša Stanković"-National Institute of the Republic of Serbia, University of Belgrade, Belgrade, 11108, Serbia.ORCID https://orcid.org/0000-0001-5384-8396
Marijana SkorićDepartment of Plant Physiology, Institute for Biological Research "Siniša Stanković"-National Institute of the Republic of Serbia, University of Belgrade, Belgrade, 11108, Serbia.ORCID https://orcid.org/0000-0002-3727-4692
Branislav ŠilerDepartment of Plant Physiology, Institute for Biological Research "Siniša Stanković"-National Institute of the Republic of Serbia, University of Belgrade, Belgrade, 11108, Serbia.ORCID https://orcid.org/0000-0001-5831-6612
Tamara LukićDepartment of Plant Physiology, Institute for Biological Research "Siniša Stanković"-National Institute of the Republic of Serbia, University of Belgrade, Belgrade, 11108, Serbia.ORCID https://orcid.org/0000-0001-8950-6304
Ana StuparDepartment of Plant Physiology, Institute for Biological Research "Siniša Stanković"-National Institute of the Republic of Serbia, University of Belgrade, Belgrade, 11108, Serbia.ORCID https://orcid.org/0009-0000-5288-0482
Slavica DmitrovićDepartment of Plant Physiology, Institute for Biological Research "Siniša Stanković"-National Institute of the Republic of Serbia, University of Belgrade, Belgrade, 11108, Serbia.ORCID https://orcid.org/0000-0002-2621-1530
Jasmina Nestorović ŽivkovićDepartment of Plant Physiology, Institute for Biological Research "Siniša Stanković"-National Institute of the Republic of Serbia, University of Belgrade, Belgrade, 11108, Serbia.ORCID https://orcid.org/0000-0001-5670-4558
Biljana FilipovićDepartment of Plant Physiology, Institute for Biological Research "Siniša Stanković"-National Institute of the Republic of Serbia, University of Belgrade, Belgrade, 11108, Serbia.ORCID https://orcid.org/0000-0001-6639-5760
Jelena BožunovićDepartment of Plant Physiology, Institute for Biological Research "Siniša Stanković"-National Institute of the Republic of Serbia, University of Belgrade, Belgrade, 11108, Serbia.ORCID https://orcid.org/0000-0001-8755-4361
Miloš TodorovićDepartment of Plant Physiology, Institute for Biological Research "Siniša Stanković"-National Institute of the Republic of Serbia, University of Belgrade, Belgrade, 11108, Serbia.ORCID https://orcid.org/0000-0002-8734-9146
Danijela MišićDepartment of Plant Physiology, Institute for Biological Research "Siniša Stanković"-National Institute of the Republic of Serbia, University of Belgrade, Belgrade, 11108, Serbia.ORCID https://orcid.org/0000-0002-5419-0773

Funding

Ministry of Science, Technological Development, and Innovation of the Republic of Serbia 451-03-136/2025-03/ 200007Ministry of Science, Technological Development, and Innovation of the Republic of Serbia 451-03-66/2024-03/200007Science Fund of the Republic of Serbia 7749433
6 · The paper itself

Abstract

Numerous members of the Nepeta genus (family Lamiaceae, subfamily Nepetoideae) are medicinal herbs and sources of important bioactive compounds. Most Nepeta species produce iridoids, which are monoterpenoids that deter herbivores and pathogens and are potential biopesticides. In Nepeta, some species produce iridoid aglycones and glycosylated iridoids (referred to as chemotype A), some produce only glycosylated iridoids (chemotype B), and some produce neither iridoid aglycones nor glycosylated iridoids (chemotype C). Here, we show that the observed diversity in iridoids is, at least partially, attributed to evolutionary gains and losses of key biosynthetic genes. Based on reconstructed phylogenetic relationships, we propose a scenario in which partial or complete loss of the ability to synthesize iridoids with specific stereochemistries in the taxa with chemotypes B and C resulted from independent evolutionary events. These observations improve our understanding of metabolic diversity in the Nepeta genus and may inform efforts to produce specific iridoids in plants.

Indexed as

IridoidsNepetaPhylogenyIridoidsbiosynthesiscatmintsiridoidsITSmetabolomicsNepetaphylogenyplastid DNA markerstranscriptomics

Identifiers

PMID41527298
PMCPMC12968361

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.