Evidence map›Paper›PMID 41527184›Full record

ArticleInfluenza and other respiratory viruses2026

Early COVID-19 and Severity of Subsequent Omicron Infection in Ontario Canada.

Caroline Kassee, Altynay Shigayeva, Christopher Kandel, Lubna Farooqi, Zoe Zhong, Anne-Claude Gingras, Brenda L Coleman, Lois Gilbert, Wayne L Gold, Maria Major and 7 more

Abstract read
In one paragraph

Article in Influenza and other respiratory viruses, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Caroline KasseeDepartment of Microbiology, Sinai Health, Toronto, Canada.
Altynay ShigayevaDepartment of Microbiology, Sinai Health, Toronto, Canada.
Christopher KandelMichael Garron Hospital, Toronto East Health Network, Toronto, Canada.
Lubna FarooqiDepartment of Microbiology, Sinai Health, Toronto, Canada.
Zoe ZhongDepartment of Microbiology, Sinai Health, Toronto, Canada.
Anne-Claude GingrasLunenfeld-Tanenbaum Research Institute, Sinai Health, Toronto, Canada.
Brenda L ColemanDepartment of Microbiology, Sinai Health, Toronto, Canada.
Lois GilbertDepartment of Microbiology, Sinai Health, Toronto, Canada.
Wayne L GoldDepartment of Medicine, University of Toronto, Toronto, Canada.
Maria MajorPfizer Canada, Kirkland, Canada.
Tony MazzulliDepartment of Microbiology, Sinai Health, Toronto, Canada.
Samira MubarekaDepartment of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Canada.
Srinivas Rao ValluriPfizer Inc., New York, New York, USA.
Catherine MartinPfizer Inc., New York, New York, USA.
Moe H KyawPfizer Inc., New York, New York, USA.
John M McLaughlinPfizer Inc., New York, New York, USA.
Allison McGeerDepartment of Microbiology, Sinai Health, Toronto, Canada.

Funding

Pfizer 68616285
6 · The paper itself

Abstract

We evaluated whether having early COVID-19 reduced the severity of subsequent Omicron infection, assessing activities of daily living (ADL), healthcare utilization and illness duration. Comparisons were made between persons with (1) early COVID-19-compatible illness with a negative test, (2) early lab-confirmed SARS-CoV-2 14-26 months and (3) early lab-confirmed SAR-CoV-2 > 26 months before Omicron infection. Among 261 patients with laboratory-confirmed Omicron, 177 (68%) had COVID-19 in 2020, a median of 793 days (IQR, 659-902) prior to Omicron infection. Compared to no early COVID-19, COVID-19 14-26 months, but not > 26 months, before was associated with reduced impact on ADL during first Omicron infection (OR 0.52, 95% CI 0.29-0.93).

Indexed as

COVID-19Activities of Daily LivingAdultAgedFemaleHumansMaleMiddle AgedOntarioSARS-CoV-2Severity of Illness Indexactivities of daily living (ADL)Omicronpre‐existing immunityprior infectionreinfectionseverity

Identifiers

PMID41527184
PMCPMC12795780

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.