ArticleCancer cell international2026
The notch-miR-188-5p-TIMP2/3 axis orchestrates exosome-driven pre-metastatic niche formation in colorectal cancer.
Article in Cancer cell international, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- Emerging roles of Notch signaling in the tumor microenvironment of digestive system cancers.Frontiers in molecular biosciences · 2026Review
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Colorectal cancer (CRC) metastasis is critically mediated by pre-metastatic niche (PMN) formation, a process driven by tumor-derived exosomes. This study establishes a highly invasive CT-26 subline (HI CT-26) through iterative in vivo selection, demonstrating enhanced metastatic potential via epithelial-mesenchymal transition (EMT) activation and transendothelial migration. HI CT-26-derived exosomes were found to enrich miR-188-5p, which directly suppresses TIMP2 and TIMP3, key regulators of extracellular matrix (ECM) homeostasis and immune modulation. This suppression is associated with the establishment of a PMN, characterized by an increased relative abundance of M2-like macrophages and myeloid-derived suppressor cell (MDSC) accumulation in target organs. Mechanistically, Notch signaling activates miR-188-5p transcription through RBP-J binding to its promoter, forming a regulatory axis that links Notch pathway activation to metastatic progression. Clinical validation using TCGA data confirmed elevated RBP-J and miR-188-5p expression, alongside reduced TIMP2/3 levels, as prognostic biomarkers for poor CRC outcomes. These findings reveal a novel Notch-miR-188-5p-TIMP2/3 signaling cascade driving exosome-mediated PMN formation, offering insights into therapeutic strategies targeting the metastatic microenvironment.
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