Evidence map›Paper›PMID 41526949›Full record

ArticleLipids in health and disease2026

Relationship between maternal lipid profile during the third trimester and the risk of small-for-gestational-age birth: exploring inadequate gestational weight gain as a mediator.

Maissam Ghanem, Weiming Wang, Huaqi Zhang, Jin Liu, Qian Liang, Nianhong Yang

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Article in Lipids in health and disease, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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4 · The record

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5 · Who and what money

Authors and funding

6 authors.

Maissam GhanemHubei Key Laboratory of Food Nutrition and Safety, MOE Key Laboratory of Environment and Health, Department of Nutrition and Food Hygiene, School of Public Health, Tongji Medical College, Huazhong University of Science & Technology, Wuhan, 430030, China.
Weiming WangHubei Key Laboratory of Food Nutrition and Safety, MOE Key Laboratory of Environment and Health, Department of Nutrition and Food Hygiene, School of Public Health, Tongji Medical College, Huazhong University of Science & Technology, Wuhan, 430030, China.
Huaqi ZhangHubei Key Laboratory of Food Nutrition and Safety, MOE Key Laboratory of Environment and Health, Department of Nutrition and Food Hygiene, School of Public Health, Tongji Medical College, Huazhong University of Science & Technology, Wuhan, 430030, China.
Jin LiuHubei Key Laboratory of Food Nutrition and Safety, MOE Key Laboratory of Environment and Health, Department of Nutrition and Food Hygiene, School of Public Health, Tongji Medical College, Huazhong University of Science & Technology, Wuhan, 430030, China.
Qian LiangHubei Key Laboratory of Food Nutrition and Safety, MOE Key Laboratory of Environment and Health, Department of Nutrition and Food Hygiene, School of Public Health, Tongji Medical College, Huazhong University of Science & Technology, Wuhan, 430030, China.
Nianhong YangHubei Key Laboratory of Food Nutrition and Safety, MOE Key Laboratory of Environment and Health, Department of Nutrition and Food Hygiene, School of Public Health, Tongji Medical College, Huazhong University of Science & Technology, Wuhan, 430030, China. zynh@mails.tjmu.edu.cn.

Funding

National Program of the Basic Research Project of China 2019FY101003, 2013FY114200
6 · The paper itself

Abstract

backgroundLipids play crucial roles in maternal and foetal metabolism; however, their effects on birth weight remain unclear. Moreover, the potential mediating role of inadequate gestational weight gain (iGWG) in this association remains unexplored. The objective of this study was to assess maternal lipid profiles in the third trimester and their associations with the risk of small-for-gestational-age (SGA) infants, focusing on the combined effects of high-density lipoprotein cholesterol (HDL-C) and triglycerides (TG). This study also examined whether iGWG influenced this relationship.

methodsData were sourced from the Tongji Maternal and Child Health Cohort. Maternal fasting lipid levels were measured during the third trimester and birth information was retrieved from medical records. Log-Poisson regression analysis was performed to assess the relationship between lipid tertiles and SGA risk. The possible mediating role of iGWG was examined using the mediation package in R.

resultsAn increased risk of SGA was associated with high HDL-C levels (adjusted relative risk [aRR], 1.54; 95% confidence interval [CI], 1.15-2.07), particularly among mothers with high HDL-C and low TG levels (aRR, 1.77; 95% CI, 1.10-2.87). This association remained significant among individuals with normal pre-pregnancy weight. The relationship between lipid profiles and SGA was independent of iGWG.

conclusionsAn increased risk of SGA was associated with high maternal HDL-C levels. The combination of low TG and high HDL-C levels was identified as a significant predictor of SGA. iGWG did not explain these associations.

Indexed as

Cholesterol, HDLGestational Weight GainInfant, Small for Gestational AgeLipidsPregnancy Trimester, ThirdTriglyceridesAdultBirth WeightFemaleHumansInfant, NewbornPregnancyRisk FactorsCholesterol, HDLLipidsTriglyceridesGestational weight gainHigh-density lipoprotein cholesterolPregnancySmall-for-gestational-ageTriglycerides

Identifiers

PMID41526949
PMCPMC12888231

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