Evidence map›Paper›PMID 41526855›Full record

ArticleBMC psychiatry2026

Polygenic risk for schizophrenia predicting test-measured and self-reported cognitive performance in individuals without psychosis.

Elena Rosenqvist, Leo-Pekka Lyytikäinen, Elina Sormunen, Mika Kähönen, Olli Raitakari, Jarmo Hietala, Katja Pahkala, Terho Lehtimäki, Liisa Keltikangas-Järvinen, Suvi Rovio and 1 more

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Article in BMC psychiatry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

11 authors.

Elena RosenqvistDepartment of Psychology, Faculty of Medicine, University of Helsinki, P.O. Box 21, Haartmaninkatu 3, Helsinki, 00014, Finland.
Leo-Pekka LyytikäinenFaculty of Medicine and Health Technology, Tampere University, Tampere, Finland.
Elina SormunenDepartment of Psychiatry, University of Turku and Turku University Hospital, Turku, Finland.
Mika KähönenDepartment of Clinical Physiology, Tampere University Hospital and Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.
Olli RaitakariResearch Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland.
Jarmo HietalaDepartment of Psychiatry, University of Turku and Turku University Hospital, Turku, Finland.
Katja PahkalaResearch Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland.
Terho LehtimäkiFaculty of Medicine and Health Technology, Tampere University, Tampere, Finland.
Liisa Keltikangas-JärvinenDepartment of Psychology, Faculty of Medicine, University of Helsinki, P.O. Box 21, Haartmaninkatu 3, Helsinki, 00014, Finland.
Suvi Rovio *Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland.
Aino Saarinen *Department of Psychology, Faculty of Medicine, University of Helsinki, P.O. Box 21, Haartmaninkatu 3, Helsinki, 00014, Finland. aino.i.saarinen@helsinki.fi.

Funding

Emil Aaltosen Säätiö 220255
6 · The paper itself

Abstract

introductionSchizophrenia is characterized by weaker test-measured cognitive performance, which is partially explained by disease-related secondary factors (after the onset of the disorder) such as side effects of antipsychotics, stigma, or sedentary behavior. We examined whether polygenic risk for schizophrenia (PRSSCZ) is associated with (a) test-measured or (b) self-reported cognitive performance in individuals who have not converted into non-affective psychosis during follow-up to extending to middle age.

methodsThe participants came from the population-based Young Finns Study, born between 1962 and 1977 (n = 2217). Participants with diagnosed non-affective psychoses were excluded from the sample. Diagnoses collected from the Care Register for Health Care. PRS

resultsIn individuals who have not developed non-affective psychoses during follow-up to middle age, high PRS

conclusionWe observed lower cognitive functioning in domains similar to those reported in studies of patients with schizophrenia. Thus, some difficulties in cognitive performance may not be fully attributable to the disorder itself but may partly reflect normative developmental trajectories in individuals with high polygenic liabilities. CLINICAL TRIAL NUMBER: Not applicable.

Indexed as

CognitionMultifactorial InheritanceSchizophreniaSchizophrenic PsychologyAdultExecutive FunctionFemaleFinlandGenetic Risk ScoreHumansMaleMiddle AgedNeuropsychological TestsPsychotic DisordersSelf ReportYoung AdultCognitive abilityCognitive functionCognitive performanceExecutive functionPsychosis

Identifiers

PMID41526855
PMCPMC12797622

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.