Evidence map›Paper›PMID 41526758›Full record

ArticlePediatric nephrology (Berlin, Germany)2026

Dialysis modality and mortality of the Contemporary Infant and Neonatal Dialysis (COINED) Cohort: a Pediatric Nephrology Research Consortium (PNRC) study.

Melissa Muff-Luett, Tennille Webb, Rebecca Scobell, Neha Pottanat, Eileen Ciccia, Donna Claes, Caitlin Carter, Sarah Nelson-Taylor, Morgan Beebe, Meredith Harris and 18 more

Abstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Pediatric nephrology (Berlin, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Neonatal continuous kidney replacement therapy.Pediatric nephrology (Berlin, Germany) · 2026
    Review
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

28 authors.

Melissa Muff-LuettDivision of Pediatric Nephrology, University of Nebraska Medical School/Children's Nebraska, 8200 Dodge St, Omaha, NE, 68114, USA. mluett@childrensnebraska.org.ORCID http://orcid.org/0000-0001-9575-8356
Tennille WebbDepartment of Pediatrics, Division of Pediatric Nephrology, University of Alabama at Birmingham/Children's of Alabama, Birmingham, AL, USA.
Rebecca ScobellDivision of Nephrology, Department of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Neha PottanatDivision of Pediatric Nephrology, Department of Pediatrics, Indiana University School of Medicine and Riley Children's Health, Indianapolis, IN, USA.
Eileen CicciaDivision of Nephrology, Hypertension, & Apheresis, Department of Pediatrics, Washington University School of Medicine, St. Louis, MO, USA.
Donna ClaesDivision of Nephrology, Department of Pediatrics, University of Cincinnati College of Medicine/Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
Caitlin CarterDepartment of Pediatrics, Division of Pediatric Nephrology, UC San Diego/Rady Children's Hospital, San Diego, CA, USA.
Sarah Nelson-TaylorDivision of Pediatric Nephrology, University of Colorado School of Medicine/Children's Hospital of Colorado, Aurora, CO, USA.
Morgan BeebeNationwide Children's Hospital, Columbus, OH, USA.
Meredith HarrisDivision of Nephrology, Ann & Robert Lurie Children's Hospital of Chicago, Chicago, IL, USA.
Issa AlhamoudDivision of Pediatric Nephrology, Stead Family Children's Hospital, University of Iowa, Iowa City, IA, USA.
Catherine JosephDivision of Pediatric Nephrology, Baylor College of Medicine, Texas Children's Hospital, Houston, TX, USA.
Matt GrinsellDivision of Nephrology and Hypertension, Department of Pediatrics, University of Utah School of Medicine, Salt Lake City, UT, USA.
Yonique PetgraveDivision of Nephrology, Department of Pediatrics, University of Tennessee Health Sciences Center, Memphis, TN, USA.
Marc B LandeDivision of Nephrology, Department of Pediatrics, University of Rochester Medical Center, Rochester, NY, USA.
Kelsey RichardsonDepartment of Pediatrics, Division of Pediatric Nephrology, Oregon Health & Science University, Portland, OR, USA.
Bakri AlzarkaDepartment of Pediatrics, Division of Pediatric Nephrology, University of Maryland School of Medicine, Baltimore, MD, USA.
Randa RazzoukCook Children's Medical Center, Fort Worth, TX, USA.
Kim PiburnDivision of Nephrology, Department of Pediatrics, The University of Texas Health Science Center at San Antonio, San Antonio, TX, USA.
Rushelle ByfieldDivision of Nephrology and Hypertension, Department of Pediatrics, Columbia University Vagelos College of Physicians and Surgeons/ New York Presbyterian-Morgan Stanley Children's Hospital, New York, NY, USA.
Hannah KimDivision of Nephrology, Penn State College of Medicine/Weill Cornell Medicine, Hershey, PA, USA.
Chryso Pefkaros KatsoufisDivision of Pediatric Nephrology, Department of Pediatrics, University of Miami Miller School of Medicine/ Holtz Children's Hospital, Miami, FL, USA.
Clare LindnerDivision of Nephrology, Department of Pediatrics C.S. Mott Children's Hospital/The University of Michigan, Ann Arbor, MI, USA.
Brendan CrawfordDivision of Nephrology, Department of Pediatrics, University of Arkansas Medical Sciences/Arkansas Children's Hospital, Little Rock, AR, USA.
Leonela VillegasDivision of Nephrology, Department of Pediatrics, Connecticut Children's Medical Center, Hartford, CT, USA.
Robin HighUniversity of Nebraska Medical School: Department of Biostatistics, College of Public Health, Omaha, NE, USA.
Elizabeth LydenUniversity of Nebraska Medical School: Department of Biostatistics, College of Public Health, Omaha, NE, USA.
Keia SandersonUniversity of North Carolina Department of Medicine-Nephrology, Chapel Hill, NC, USA.

Funding

Machine Learning Risk Prediction of Kidney Disease After Extremely Preterm BirthK23DK131289 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI SANDERSON, KEIA · 2023 to 2025
$602k
NIDDK NIH HHS L40DK130155NINR NIH HHS K23DK131289
6 · The paper itself

Abstract

backgroundRecent technologic advances in neonatal dialysis have changed current dialysis practices. The goal of this study was to define demographics, diagnoses, initial dialysis modality, modality changes, and outcomes of neonates receiving dialysis.

methodsRetrospective, multicenter cohort of neonates (≤ 30 days of age) from 26 U.S. centers, who received dialysis between 6/2017 and 5/2022. Measures of central tendency were calculated to describe the cohort stratified by the primary dialysis-related diagnosis including acute kidney injury requiring dialysis (AKI-D), stage 5 chronic kidney disease (CKD 5), hyperammonemia, and other causes. The primary outcome was death during the initial hospitalization.

resultsFor the 405 neonates in this cohort, AKI-D (57%) was the most common dialysis-related diagnosis, followed by CKD 5 (29%) and hyperammonemia (11%). Most neonates (58%) had a birth weight between 2500 and 3500 g. The most common initial neonatal dialysis modality was continuous kidney replacement therapy (CKRT) with (35%) or without extracorporeal membrane oxygenation (ECMO) (36%). Only 26% of neonates received peritoneal dialysis (PD) as their initial dialysis modality. Thirty percent of neonates received more than one dialysis modality. The overall mortality was 50% (59% in AKI-D and 41% in CKD 5). Withdrawal of care was reported as the most common reason for death. The odds of death were lower for neonates with AKI-D receiving PD as the initial modality when compared to CKRT (aOR 0.28, 95% CI 0.09-0.84) or CKRT with ECMO (aOR 0.24, 95% CI 0.10-0.58), but this association was not seen in neonates with CKD 5.

conclusionsThis multicenter, contemporary neonatal dialysis cohort shows increased use of CKRT as the initial dialysis modality but also shows that the mortality of neonates on dialysis remains high. Additional studies on modern neonatal dialysis are needed.

Indexed as

Acute Kidney InjuryContinuous Renal Replacement TherapyKidney Failure, ChronicRenal DialysisExtracorporeal Membrane OxygenationFemaleHumansInfantInfant, NewbornMalePeritoneal DialysisRetrospective StudiesUnited StatesAKICKRTNeonatal dialysisPeritoneal dialysisStage 5 CKD

Identifiers

PMID41526758
PMCPMC13139246

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.