Factors Associated with the Severity of Female Pattern Hair Loss: A Retrospective Study.

Meiling Jian, Dan Zhang, Xingang Fu, Yuheng Cheng, Xiaoyu Sun, Zhibin Wang, Lin Li

Abstract read

In one paragraph

Article in Aesthetic plastic surgery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

7 authors.

Meiling JianDepartment of Laboratory Medicine and Sichuan Provincial Key Laboratory for Human Disease Gene Study, Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, No. 32, West Second Section First Ring Rd., Chengdu, 610072, Sichuan, China.

Dan ZhangDepartment of Laboratory Medicine and Sichuan Provincial Key Laboratory for Human Disease Gene Study, Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, No. 32, West Second Section First Ring Rd., Chengdu, 610072, Sichuan, China.

Xingang FuDepartment of Laboratory Medicine and Sichuan Provincial Key Laboratory for Human Disease Gene Study, Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, No. 32, West Second Section First Ring Rd., Chengdu, 610072, Sichuan, China.

Yuheng ChengDepartment of Laboratory Medicine and Sichuan Provincial Key Laboratory for Human Disease Gene Study, Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, No. 32, West Second Section First Ring Rd., Chengdu, 610072, Sichuan, China.

Xiaoyu SunDepartment of Laboratory Medicine and Sichuan Provincial Key Laboratory for Human Disease Gene Study, Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, No. 32, West Second Section First Ring Rd., Chengdu, 610072, Sichuan, China.

Zhibin WangDepartment of Laboratory Medicine and Sichuan Provincial Key Laboratory for Human Disease Gene Study, Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, No. 32, West Second Section First Ring Rd., Chengdu, 610072, Sichuan, China. 404102198@qq.com.

Lin LiDepartment of Laboratory Medicine and Sichuan Provincial Key Laboratory for Human Disease Gene Study, Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, No. 32, West Second Section First Ring Rd., Chengdu, 610072, Sichuan, China. lil@uestc.edu.cn.

Funding

National Natural Science Foundation of China 82572687

6 · The paper itself

Abstract

backgroundFemale pattern hair loss (FPHL) has a severe impact on physical and mental well-being. The aim of this study is to assess factors associated with the severity of FPHL.

methodsThis retrospective study included 289 patients with FPHL (150 classified as F1 and 139 as F2/3). Thirteen elements were determined using an Inductively Coupled Plasma Mass Spectrometry method. Univariate and multivariate analyses, propensity score-matched (PSM) models, and restricted cubic spline (RCS) analyses were applied to investigate associations and dose-response relationships between elements, vitamins, hormones and FPHL severity

resultsPatients in the F2/3 group were significantly older than those in the F1 group (P = 0.002) and had a longer duration of FPHL (P < 0.001). Serum levels of selenium (Se), zinc (Zn), vitamin B9, and testosterone were significantly lower in the F2/3 group compared with the F1 group (all P < 0.05). However, multivariate analysis demonstrated that only disease duration remained an independent risk factor for increased FPHL severity (OR 1.123 [95% CI 1.047-1.211]; P = 0.02), which was further validated by RCS analysis. After PSM adjustment of demographic characteristics, no significant differences in elements, vitamins, or hormone levels were observed between the F1 and F2/3 groups.

conclusionsElements, vitamins, and hormones were not predictors of FPHL after adjustment for demographic characteristics. Larger prospective cohort studies are warranted to validate these findings. LEVEL OF EVIDENCE III: This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266 .

Indexed as

AlopeciaAdultFemaleHumansMultivariate AnalysisPropensity ScoreRetrospective StudiesRisk AssessmentRisk FactorsSeverity of Illness IndexSpectrophotometry, AtomicElementsFemale pattern hair lossHormonesICP-MSPropensity score matchingVitamins

Identifiers

PMID41526740

DOI10.1111/j.1365-2133.2009.09588.x

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.