Evidence map›Paper›PMID 41526719›Full record

ArticleEMBO reports2026

p16

Tingting Yang, Qiulian Zhou, Yihua Bei, Danni Meng, Songwei Ai, Yuhui Zhang, Jian Zhang, Li Liu, Hongjian Chen, Xue Pan and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in EMBO reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Tingting Yang *Cardiac Regeneration and Ageing Lab, Institute of Geriatrics (Shanghai University), Affiliated Nantong Hospital of Shanghai University (The Sixth People's Hospital of Nantong) and School of Life Science, Shanghai University, Nantong, 226011, China.ORCID http://orcid.org/0009-0009-0116-3518
Qiulian Zhou *Institute of Cardiovascular Sciences, Shanghai Engineering Research Center of Organ Repair, Joint International Research Laboratory of Biomaterials and Biotechnology in Organ Repair (Ministry of Education), School of Life Science, Shanghai University, Shanghai, 200444, China.ORCID http://orcid.org/0000-0003-0649-1835
Yihua Bei *Cardiac Regeneration and Ageing Lab, Institute of Geriatrics (Shanghai University), Affiliated Nantong Hospital of Shanghai University (The Sixth People's Hospital of Nantong) and School of Life Science, Shanghai University, Nantong, 226011, China.ORCID http://orcid.org/0000-0002-2727-7187
Danni MengCardiac Regeneration and Ageing Lab, Institute of Geriatrics (Shanghai University), Affiliated Nantong Hospital of Shanghai University (The Sixth People's Hospital of Nantong) and School of Life Science, Shanghai University, Nantong, 226011, China.
Songwei AiCardiac Regeneration and Ageing Lab, Institute of Geriatrics (Shanghai University), Affiliated Nantong Hospital of Shanghai University (The Sixth People's Hospital of Nantong) and School of Life Science, Shanghai University, Nantong, 226011, China.
Yuhui ZhangState Key Laboratory of Cardiovascular Disease, Heart Failure Center, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, 100037, China.
Jian ZhangState Key Laboratory of Cardiovascular Disease, Heart Failure Center, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, 100037, China.
Li LiuCardiac Regeneration and Ageing Lab, Institute of Geriatrics (Shanghai University), Affiliated Nantong Hospital of Shanghai University (The Sixth People's Hospital of Nantong) and School of Life Science, Shanghai University, Nantong, 226011, China.
Hongjian ChenCardiac Regeneration and Ageing Lab, Institute of Geriatrics (Shanghai University), Affiliated Nantong Hospital of Shanghai University (The Sixth People's Hospital of Nantong) and School of Life Science, Shanghai University, Nantong, 226011, China.
Xue PanCardiac Regeneration and Ageing Lab, Institute of Geriatrics (Shanghai University), Affiliated Nantong Hospital of Shanghai University (The Sixth People's Hospital of Nantong) and School of Life Science, Shanghai University, Nantong, 226011, China.
Xiaohang YinCardiac Regeneration and Ageing Lab, Institute of Geriatrics (Shanghai University), Affiliated Nantong Hospital of Shanghai University (The Sixth People's Hospital of Nantong) and School of Life Science, Shanghai University, Nantong, 226011, China.
Michail SpanosCardiovascular Division of the Massachusetts General Hospital and Harvard Medical School, Boston, MA, 02114, USA.ORCID http://orcid.org/0000-0003-1205-4201
Guoping LiCardiovascular Division of the Massachusetts General Hospital and Harvard Medical School, Boston, MA, 02114, USA.ORCID http://orcid.org/0000-0003-3874-0744
Dragos CretoiuDepartment of Medical Genetics, Carol Davila University of Medicine and Pharmacy, Bucharest, 020031, Romania.ORCID http://orcid.org/0000-0003-3214-030X
Joost P G SluijterDepartment of Cardiology, Laboratory of Experimental Cardiology, University Medical Center Utrecht, Utrecht, 3508GA, The Netherlands.
Anthony RosenzweigStanley and Judith Frankel Institute for Heart and Brain Health, University of Michigan Medical Center, Ann Arbor, MI, 48109, USA. anthros@med.umich.edu.ORCID http://orcid.org/0000-0001-6387-0386
Junjie XiaoCardiac Regeneration and Ageing Lab, Institute of Geriatrics (Shanghai University), Affiliated Nantong Hospital of Shanghai University (The Sixth People's Hospital of Nantong) and School of Life Science, Shanghai University, Nantong, 226011, China. junjiexiao@shu.edu.cn.ORCID http://orcid.org/0000-0002-9202-0003

Funding

Understanding the Cardiac Benefits of Exercise at the Cellular and Molecular LevelR35HL155318 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ANTHONY ROSENZWEIG · 2021 to 2026
$5.4M
Role of Activin Type II receptor signaling in age-related heart failureR01AG061034 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ROSENZWEIG, ANTHONY · 2019 to 2023
$3.0M
China Postdoctoral Science Foundation () 2023M742205Dawn Program of Shanghai Education Commission 24SG36National Natural Science Foundation of China 81873472National Natural Science Foundation of China 82020108002National Natural Science Foundation of China 82170285National Natural Science Foundation of China 82200321National Natural Science Foundation of China 82225005National Natural Science Foundation of China 82401851NIH HHS R01AG061034NIH HHS R35HL155318Oriental Scholars of Shanghai Universities TP2022057Postdoctoral Fellowship Program of CPSF GZB20230398Science and Technology Commission of Shanghai Municipality (STCSM) 23010500300Science and Technology Commission of Shanghai Municipality (STCSM) 23410750100Shanghai Sailing Program 21YF1413200The American Heart Association 23MERIT1038415
6 · The paper itself

Abstract

Myocardial ischemia-reperfusion (I/R) injury remains a significant challenge in cardiovascular medicine, with its molecular mechanisms still not fully understood. Screening the GEO and Comparative Toxicogenomics Database as well as spatial multi-omics data, we identify Cdkn2a, encoding p16

Indexed as

Cardiac Ischemia/Reperfusion InjuryNpas2 mRNA Stability and Translationp16INK4aSlco1a4

Identifiers

PMID41526719
PMCPMC12936097

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.