Evidence map›Paper›PMID 41526679›Full record

ArticleJournal of perinatology : official journal of the California Perinatal Association2026

A multicenter descriptive study of neonatal-onset urea cycle disorder patients hospitalized in level IV NICUs.

Whitney S Thompson, Ellen M Bendel-Stenzel, Isabella Zaniletti, Theresa R Grover, Karna Murthy, Michael A Padula, Queenie K G Tan, Kristen R Suhrie

Abstract readMulticenter Study
PubMed Publisher
In one paragraph

Article in Journal of perinatology : official journal of the California Perinatal Association, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Whitney S ThompsonMayo Clinic, Rochester, MN, USA. Thompson.Whitney@mayo.edu.ORCID http://orcid.org/0009-0000-5148-6379
Ellen M Bendel-StenzelMayo Clinic, Rochester, MN, USA.ORCID http://orcid.org/0000-0001-5367-3039
Isabella ZanilettiChildren's Hospitals Neonatal Consortium, Dover, DE, USA.ORCID http://orcid.org/0000-0003-1234-3468
Theresa R GroverChildren's Hospitals Neonatal Consortium, Dover, DE, USA.
Karna MurthyChildren's Hospitals Neonatal Consortium, Dover, DE, USA.
Michael A PadulaChildren's Hospitals Neonatal Consortium, Dover, DE, USA.ORCID http://orcid.org/0000-0003-2050-5930
Queenie K G TanMayo Clinic, Rochester, MN, USA.
Kristen R SuhrieIndiana University School of Medicine and Riley Children's Hospital, Indianapolis, IN, USA.ORCID http://orcid.org/0000-0003-2572-936X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThe objective of this study was to characterize the neonatal intensive care unit (NICU) course and outcomes for infants with neonatal-onset urea cycle disorders (UCDs). STUDY

designUsing the multicenter Children's Hospitals Neonatal Database, a descriptive, retrospective cohort study was performed to characterize the presentation, interventions, comorbidities, and hospital outcomes for 176 patients with neonatal-onset UCDs that required level IV NICU care.

resultsThe median age of presentation was 5 [3,7] days, with 167 (95%) infants requiring transfer to a level IV NICU. Renal replacement therapy was undertaken for at least 34 (20%) patients. Neurologic complications occurred most frequently, with 71 (40%) patients affected. Twenty-one (12%) infants experienced in-hospital mortality. Interventions, complications, and mortality were observed most frequently in the ornithine transcarbamylase deficiency group.

conclusionNeonatal-onset UCDs are associated with significant morbidity and mortality, but heterogeneity exists among the specific named UCDs.

Indexed as

Intensive Care Units, NeonatalUrea Cycle Disorders, InbornFemaleHospital MortalityHumansInfantInfant, NewbornMaleRenal Replacement TherapyRetrospective Studies

Identifiers

PMID41526679

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.