Evidence map›Paper›PMID 41526668›Full record

ArticleScientific reports2026

Regional ventilation-perfusion changes after endobronchial valve therapy assessed by single-photon emission computed tomography in adults with severe COPD.

Dipan Karmali, Partha Ghosh, Bruce Spottiswoode, Sixto Arias, Michael Lester, Gabrielle Aguilar, Kinjal Nakrani, Kenedie St Mary, Naresh Punjabi, Trishul Siddharthan

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Dipan KarmaliDivision of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, Miller School of Medicine, University of Miami, 1951 NW 7th Ave, Suite 2308, Miami, FL, 33136, USA.
Partha GhoshSiemens Medical Solutions USA, Inc., Knoxville, TN, USA.
Bruce SpottiswoodeSiemens Medical Solutions USA, Inc., Hoffman Estates, IL, USA.
Sixto AriasDivision of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, Miller School of Medicine, University of Miami, 1951 NW 7th Ave, Suite 2308, Miami, FL, 33136, USA.
Michael LesterDivision of Allergy, Pulmonary, and Critical Care Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
Gabrielle AguilarDivision of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, Miller School of Medicine, University of Miami, 1951 NW 7th Ave, Suite 2308, Miami, FL, 33136, USA.
Kinjal NakraniDivision of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, Miller School of Medicine, University of Miami, 1951 NW 7th Ave, Suite 2308, Miami, FL, 33136, USA.
Kenedie St MaryDivision of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, Miller School of Medicine, University of Miami, 1951 NW 7th Ave, Suite 2308, Miami, FL, 33136, USA.
Naresh PunjabiDivision of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, Miller School of Medicine, University of Miami, 1951 NW 7th Ave, Suite 2308, Miami, FL, 33136, USA.
Trishul SiddharthanDivision of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, Miller School of Medicine, University of Miami, 1951 NW 7th Ave, Suite 2308, Miami, FL, 33136, USA. tsiddhar@miami.edu.

Funding

Air Pollution, Sleep-Disordered Breathing, and Biomarkers of Sudden Cardiac Death Risk in Resource-Limited SettingsF32HL182345 · NHLBI · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI Dipan Nishikant Karmali · 2025 to 2026
$110k
NHLBI NIH HHS F32 HL182345NHLBI NIH HHS F32HL182345
6 · The paper itself

Abstract

Bronchoscopic lung volume reduction (BLVR) is an established treatment for patients with severe chronic obstructive pulmonary disease (COPD), characterized as emphysema and hyperinflation, but current methods of patient selection and lobe identification are limited due to invasiveness, lack of specificity, and poor regional ventilation and perfusion assessments. This study aimed to evaluate lobar changes in ventilation, perfusion, and volume before and after endobronchial valve (EBV) placement using SPECT/CT imaging in patients with severe emphysema, and to assess their association with clinical outcomes. A prospective, single-center, pilot study enrolled six patients with severe COPD (FEV

Indexed as

PneumonectomyPulmonary Disease, Chronic ObstructiveVentilation-Perfusion RatioAgedBronchoscopyFemaleHumansMaleMiddle AgedPilot ProjectsProspective StudiesRespiratory Function TestsSingle Photon Emission Computed Tomography Computed TomographyTomography, Emission-Computed, Single-PhotonEndobronchial valvesLung volume reductionPerfusionSPECTVentilation

Identifiers

PMID41526668
PMCPMC12881539

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.